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SSR1
Identifikatori
Aliasi	SSR1
Vanjski ID-jevi	OMIM: 600868 MGI: 105082 HomoloGene: 2368 GeneCards: SSR1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	7,347,446 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	38,178,193 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum;
Biološki proces	• IRE1-mediated unfolded protein response; • cotranslational protein targeting to membrane; • positive regulation of cell population proliferation;
	Izvori:Amigo / QuickGO
Ortolozi
	6745
	107513
	ENSG00000124783
	ENSMUSG00000021427
	P43307
	Q9CY50
	NM_001292008; NM_003144
	NM_025965; NM_001360842
	NP_001278937; NP_003135
	NP_080241; NP_001347771
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica alfa translokonu pridruženog proteina jest protein koji je kod ljudi kodiran genom SSR1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 286 aminokiselina, а molekulska težina 32.235 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRLLPRLLLL	LLLVFPATVL	FRGGPRGLLA	VAQDLTEDEE	TVEDSIIEDE
DDEAEVEEDE	PTDLVEDKEE	EDVSGEPEAS	PSADTTILFV	KGEDFPANNI
VKFLVGFTNK	GTEDFIVESL	DASFRYPQDY	QFYIQNFTAL	PLNTVVPPQR
QATFEYSFIP	AEPMGGRPFG	LVINLNYKDL	NGNVFQDAVF	NQTVTVIERE
DGLDGETIFM	YMFLAGLGLL	VIVGLHQLLE	SRKRKRPIQK	VEMGTSSQND
VDMSWIPQET	LNQINKASPR	RLPRKRAQKR	SVGSDE

Funkcija

Receptor signalne sekvence (SSR) je glikozilirani endoplazmatski retikulum (ER), membranski receptor povezan s translokacijom proteina preko membrane ER. SSR se sastoji od dvije podjedinice, 34-kD glikoproteina kodiranog ovim genom i 22-kD-skog glikoproteina. Ovaj gen stvara nekoliko tipova iRNK, kao rezultat složene alternativne poliadenilacije. Ovaj gen je neobičan po tome što koristi sekvence poliA signalnih sekvenci koje su isključivo nekanonske.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124783 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021427 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SSR1 signal sequence receptor, alpha (translocon-associated protein alpha)".
^ "UniProt, P43307" (jezik: engleski). Pristupljeno 5. 10. 2021.

Dopunska literatura

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Vogel F, Hartmann E, Görlich D, Rapoport TA (1991). "Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane". Eur. J. Cell Biol. 53 (2): 197–202. PMID 1964414.
Hartmann E, Görlich D, Kostka S, et al. (1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum" (PDF). Eur. J. Biochem. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. hdl:11858/00-001M-0000-0015-3BD2-F. PMID 7916687.
Hartmann E, Prehn S (1994). "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges". FEBS Lett. 349 (3): 324–6. doi:10.1016/0014-5793(94)00693-8. PMID 8050590. S2CID 42968119.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hirama T, Miller CW, Koeffler HP (1999). "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation". FEBS Lett. 455 (3): 223–7. doi:10.1016/S0014-5793(99)00885-6. PMID 10437777. S2CID 9426244.
Wang L, Dobberstein B (1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Lett. 457 (3): 316–22. doi:10.1016/S0014-5793(99)01075-3. PMID 10471800. S2CID 22341517.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124783 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021427 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SSR1 signal sequence receptor, alpha (translocon-associated protein alpha)".

[UniProt-6] "UniProt, P43307" (jezik: engleski). Pristupljeno 5. 10. 2021.

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SSR1

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

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