SSCEL
Scijelin je protein koji je kod ljudi kodiran genom SCEL.[5][6]
Protein kodiran ovim genom je prekursor orožnjalog omotača terminalno diferenciranih keratinocita. Ovaj protein se lokalizira na periferiji ćelija i može funkcionirati u sastavljanju ili regulaciji proteina u rožnoj ovojnici. Postoje varijante transkripta koje kodiraju različite izoforme. Varijanta transkripta koja koristi alternativu polyA signal opisana je u literaturi, ali njena dužina nije utvrđena.[6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 688 aminokiselina, a molekulska težina 77 552 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSNVTLRKMS | PTGNEMKSTT | QGTTRKQQDF | HEVNKRRTFL | QDNSWIKKRP | ||||
| EEEKDENYGR | VVLNRHNSHD | ALDRKVNERD | VPKATISRYS | SDDTLDRISD | ||||
| RNDAAKTYKA | NTLDNQLTNR | SMSMFRSLEV | TKLQPGGSLN | ANTSNTIAST | ||||
| SATTPVKKKR | QSWFPPPPPG | YNASSSTGTR | RREPGVHPPI | PPKPSSPVSS | ||||
| PNQLRQDNRQ | IHPPKPGVYT | ETNRSAERNI | RSQDLDNIVK | VATSLQRSDK | ||||
| GEELDNLIKM | NKSLNRNQGL | DSLFRANPKV | EEREKRAKSL | ESLIYMSTRT | ||||
| DKDGKGIQSL | GSPIKVNQRT | DKNEKGRQNL | ESVAKVNARM | NKTSRRSEDL | ||||
| DNATEVNPKG | HENTTGKKDL | DGLIKVDPET | NKNITRGQSL | DNLIKVTPEV | ||||
| KRSNQGSKDL | NNFIKVYPGT | EKSTEGGQSL | DSLIKVTPER | NRTNQGNQDL | ||||
| ENLIKVIPSA | NKSSEQGLDE | HINVSPKAVK | NTDGKQDLDK | LIKVNPEIFT | ||||
| NNQRNQDLAN | LIKVNPAVIR | NNQSQDLDNL | IKVKPSALRN | TNRDQNLENL | ||||
| IEVNSHVSEN | KNGSSNTGAK | QAGPQDTVVY | TRTYVENSKS | PKDGYQENIS | ||||
| GKYIQTVYST | SDRSVIERDM | CTYCRKPLGV | ETKMILDELQ | ICCHSTCFKC | ||||
| EICKQPLENL | QAGDSIWIYR | QTIHCEPCYS | KIMAKWIP |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136155 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022123 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Champliaud MF, Burgeson RE, Jin W, Baden HP, Olson PF (Dec 1998). "cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope". J Biol Chem. 273 (47): 31547–54. doi:10.1074/jbc.273.47.31547. PMID 9813070.
- ^ a b "Entrez Gene: SCEL sciellin".
- ^ "UniProt, O95171". Pristupljeno 5. 8. 2021.
Dopunska literatura
- Corona W, Karkera DJ, Patterson RH, et al. (2004). "Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma". Anticancer Res. 24 (3a): 1417–9. PMID 15274303.
- Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". J. Invest. Dermatol. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Champliaud MF, Baden HP, Koch M, et al. (2001). "Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties". Genomics. 70 (2): 264–8. doi:10.1006/geno.2000.6390. PMID 11112355.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Kvedar JC, Manabe M, Phillips SB, et al. (1992). "Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes". Differentiation. 49 (3): 195–204. doi:10.1111/j.1432-0436.1992.tb00667.x. PMID 1377656.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.