SSC4D

SSC4D
Identifikatori
AliasiSSC4D
Vanjski ID-jeviOMIM: 607639 MGI: 1924709 HomoloGene: 34137 GeneCards: SSC4D
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za SSC4D
Genomska lokacija za SSC4D
Bend7q11.23Početak76,389,334 bp[1]
Kraj76,409,697 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za SSC4D
Genomska lokacija za SSC4D
Bend5|5 G2Početak135,989,065 bp[2]
Kraj136,003,385 bp[2]
Ontologija gena
Molekularna funkcija• scavenger receptor activity
Ćelijska komponenta• membrana
• extracellular region
• external side of plasma membrane
Biološki proces• receptor-mediated endocytosis
• vesicle-mediated transport
• Endocitoza
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

136853

109267

Ensembl

ENSG00000146700

ENSMUSG00000029699

UniProt

Q8WTU2

A1L0T3

RefSeq (mRNK)

NM_080744

NM_001160366

RefSeq (bjelančevina)

NP_542782

NP_001153838

Lokacija (UCSC)Chr 7: 76.39 – 76.41 MbChr 5: 135.99 – 136 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Član skavengerske porodice proteina bogatih cisteinom sa četiri domena jest protein koji je kod ljudi kodiran genom SSC4D. [5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 575 aminokiselina, а molekulska težina 60.819 Da.[6]

1020304050
MHKEAEMLIGPQLDEKRWGWRLGDGSAAPPFLPQALSFLLLLPLASALQP
TPLPFQELRLVGGPSRCRGRLEVMHGGSWGSVCDDDWDVVDANVVCRQLG
CGLALPVPRPLAFGQGRGPILLDNVECRGQEAALSECGSRGWGVHNCFHY
EDVAVLCDEFLPTQPPTRKMLTSRAPPTTLPNGKSEGSVRLVGGANLCQG
RVEILHSGLWGTVCDDDWGLPDAAVVCRQLGCGAAMAATTNAFFGYGTGH
ILLDNVHCEGGEPRLAACQSLGWGVHNCGHHEDAGALCAGLGPPTLTALP
SSATREDWAWQTDPSATGVGPQPSRETALLTTAAWAAGKKSGRLRLVGGP
GPCRGRVEVLHAGGWGTVCDDDWDFADARVACREAGCGPALGATGLGHFG
YGRGPVLLDNVGCAGTEARLSDCFHLGWGQHNCGHHEDAGALCAGPEELG
LQVQQDGSETTRVPTPRPRDGHLRLVNGAHRCEGRVELYLGQRWGTVCDD
AWDLRAAGVLCRQLGCGQALAAPGEAHFGPGRGPILLDNVKCRGEESALL
LCSHIRWDAHNCDHSEDASVLCQPS

Funkcija

Proteinski domen skavengerskog receptora bogatog cisteinom (SRCR) je stara i visoko konzervirana grupa površinskih ćelijskih i/ili izlučenih proteina, od kojih su neki uključeni u razvoj imunskog sistema i regulaciju urođenog i adaptivnih imunskih odgovora. SRCR domeni grupe B obično sadrže po osam pravilno raspoređenih cistein,a koji uzrokuju dobro definiran unutardomen disulfidne veze.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146700 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029699 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Scavenger receptor cysteine rich family member with 4 domains". Pristupljeno 5. 9. 2016.
  6. ^ "UniProt, Q8WTU2" (jezik: engleski). Zanemaren tekst "2021-09-29" (pomoć)

Dopunska literatura

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