SPA17
Spermnopovršinski protein Sp17 je protein koji je kod ljudi kodiran genom SPA17.[5][6]
Ovaj gen kodira protein na površini ćelije. Studije na kunićima ukazuju na to da je u spermni protein uključen u oplodnju, vezanjem za zona pellucida oocita. Druge studije na kunićima ukazuju na to da je također uključen u dodatne adhezijske funkcije ćelija-ćelija kao što su migracija imunskih ćelija i metastaze.[6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 151 aminokiselina, а molekulska težina 17.406 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSIPFSNTHY | RIPQGFGNLL | EGLTREILRE | QPDNIPAFAA | AYFESLLEKR | ||||
| EKTNFDPAEW | GSKVEDRFYN | NHAFEEQEPP | EKSDPKQEES | QISGKEEETS | ||||
| VTILDSSEED | KEKEEVAAVK | IQAAFRGHIA | REEAKKMKTN | SLQNEEKEEN | ||||
| K |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000064199 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001948 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta. 1307 (3): 263–6. doi:10.1016/0167-4781(96)00077-2. PMID 8688458.
- ^ a b "Entrez Gene: SPA17 sperm autoantigenic protein 17".
- ^ "UniProt, Q15506". Pristupljeno 27. 8. 2021.
Dopunska literatura
- McLeskey SB, Dowds C, Carballada R, et al. (1997). Molecules involved in mammalian sperm-egg interaction. Int. Rev. Cytol. International Review of Cytology. 177. str. 57–113. doi:10.1016/S0074-7696(08)62231-7. ISBN 9780123645814. PMID 9378618.
- Richardson RT, Yamasaki N, O'Rand MG (1994). "Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. doi:10.1006/dbio.1994.1285. PMID 7525387.
- Kong M, Richardson RT, Widgren EE, O'Rand MG (1995). "Sequence and localization of the mouse sperm autoantigenic protein, Sp17". Biol. Reprod. 53 (3): 579–90. doi:10.1095/biolreprod53.3.579. PMID 7578682.
- Fujita A, Nakamura K, Kato T, et al. (2000). "Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella". J. Cell Sci. 113 (1): 103–12. PMID 10591629.
- Wen Y, Richardson RT, Widgren EE, O'Rand MG (2001). "Characterization of Sp17: a ubiquitous three domain protein that binds heparin". Biochem. J. 357 (Pt 1): 25–31. doi:10.1042/0264-6021:3570025. PMC 1221924. PMID 11415432.
- De Jong A, Buchli R, Robbins D (2003). "Characterization of sperm protein 17 in human somatic and neoplastic tissue". Cancer Lett. 186 (2): 201–9. doi:10.1016/S0304-3835(02)00350-6. PMID 12213290.
- Buchli R, De Jong A, Robbins DL (2002). "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model". Biochim. Biophys. Acta. 1578 (1–3): 29–42. doi:10.1016/S0167-4781(02)00478-5. PMID 12393185.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding". Reproduction. 124 (6): 767–74. doi:10.1530/rep.0.1240767. PMID 12530914.
- Takeoka Y, Kenny TP, Yago H, et al. (2004). "Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes". Dev. Immunol. 9 (2): 97–102. doi:10.1080/1044667021000095186. PMC 2276097. PMID 12739786.
- Chiriva-Internati M, Wang Z, Pochopien S, et al. (2004). "Identification of a sperm protein 17 CTL epitope restricted by HLA-A1". Int. J. Cancer. 107 (5): 863–5. doi:10.1002/ijc.11486. PMID 14566839. S2CID 30452400.
- Straughn JM, Shaw DR, Guerrero A, et al. (2004). "Expression of sperm protein 17 (Sp17) in ovarian cancer". Int. J. Cancer. 108 (6): 805–11. doi:10.1002/ijc.11617. PMID 14712480. S2CID 20294805.
- Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. Biol. Endocrinol. 2: 57. doi:10.1186/1477-7827-2-57. PMC 484205. PMID 15257753.
- Wang Z, Zhang Y, Ramsahoye B, et al. (2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer. 91 (8): 1597–603. doi:10.1038/sj.bjc.6602160. PMC 2409933. PMID 15381930.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gupta G, Sharma R, Chattopadhyay TK, et al. (2007). "Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer". Int. J. Cancer. 120 (8): 1739–47. doi:10.1002/ijc.22463. PMID 17230514. S2CID 31927317.
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