SP140

SP140
Dostupne strukture
PDBPretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova

2MD7, 2MD8

Identifikatori
AliasiSP140
Vanjski ID-jeviOMIM: 608602 MGI: 3702467 HomoloGene: 128391 GeneCards: SP140
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za SP140
Genomska lokacija za SP140
Bend2q37.1Početak230,203,110 bp[1]
Kraj230,313,215 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za SP140
Genomska lokacija za SP140
Bend1|1 C5Početak85,600,378 bp[2]
Kraj85,645,037 bp[2]
Ontologija gena
Molekularna funkcija• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• vezivanje sa DNK
• GO:0001948, GO:0016582 vezivanje za proteine
• vezivanje iona metala
Ćelijska komponenta• citoplazma
• PML body
• nuclear envelope
• mitohondrija
• jedro
• nukleoplazma
• fibrillar center
• nuclear body
Biološki proces• defense response
• GO:0009373 regulation of transcription, DNA-templated
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

11262

434484

Ensembl

ENSG00000079263

ENSMUSG00000070031

UniProt

Q13342

n/a

RefSeq (mRNK)

NM_001005176
NM_001278451
NM_001278452
NM_001278453
NM_007237

NM_001013817

RefSeq (bjelančevina)

NP_001005176
NP_001265380
NP_001265381
NP_001265382
NP_009168

n/a

Lokacija (UCSC)Chr 2: 230.2 – 230.31 MbChr 1: 85.6 – 85.65 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein jedarnog tijela SP14 jest protein koji je kod ljudi kodiran genom SP140 sa hromosoma 2.[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 867 aminokiselina, a molekulska težina 98.223 Da.[6]

1020304050
MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENK
VEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLS
ELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVND
LEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQL
ALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLPYDTEVLE
SNGMIDAARTYSTAPGEKQGEEEGRNSPRKRNQDKEKYQESPEGRDKETF
DLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARC
GSVSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEE
RQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYE
NEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRR
KKRGHGWSRMRMRRQENSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGR
KRGKPGTRFTQSDRAAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGI
LHKKKLQQGILVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSVRCGGWP
LRWLMENGFLPDPPRIRYRKKKRILKSQNNSSVDPCMRNLDECEVCRDGG
ELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKESPGSQQCCQESEV
LERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMW
LDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEF
EKNFKEVFAIQETNGNN

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079263 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070031 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SP140 nuclear body protein". Pristupljeno 7. 9. 2016.
  6. ^ "UniProt, Q13342" (jezik: engleski). Pristupljeno 19. 11. 2021.

Dopunska literatura

Vanjski linkovi

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear body protein SP140

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