SKIV2L2
2-liki protein superubitačne virusicidne aktivnosti 2 jest protein koji je kod ljudi kodiran genom SKIV2L2 sa hromosoma 5.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.042 aminokiseline, а molekulska težina 117.805 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MADAFGDELF | SVFEGDSTTA | AGTKKDKEKD | KGKWKGPPGS | ADKAGKRFDG | ||||
| KLQSESTNNG | KNKRDVDFEG | TDEPIFGKKP | RIEESITEDL | SLADLMPRVK | ||||
| VQSVETVEGC | THEVALPAEE | DYLPLKPRVG | KAAKEYPFIL | DAFQREAIQC | ||||
| VDNNQSVLVS | AHTSAGKTVC | AEYAIALALR | EKQRVIFTSP | IKALSNQKYR | ||||
| EMYEEFQDVG | LMTGDVTINP | TASCLVMTTE | ILRSMLYRGS | EVMREVAWVI | ||||
| FDEIHYMRDS | ERGVVWEETI | ILLPDNVHYV | FLSATIPNAR | QFAEWICHLH | ||||
| KQPCHVIYTD | YRPTPLQHYI | FPAGGDGLHL | VVDENGDFRE | DNFNTAMQVL | ||||
| RDAGDLAKGD | QKGRKGGTKG | PSNVFKIVKM | IMERNFQPVI | IFSFSKKDCE | ||||
| AYALQMTKLD | FNTDEEKKMV | EEVFSNAIDC | LSDEDKKLPQ | VEHVLPLLKR | ||||
| GIGIHHGGLL | PILKETIEIL | FSEGLIKALF | ATETFAMGIN | MPARTVLFTN | ||||
| ARKFDGKDFR | WISSGEYIQM | SGRAGRRGMD | DRGIVILMVD | EKMSPTIGKQ | ||||
| LLKGSADPLN | SAFHLTYNMV | LNLLRVEEIN | PEYMLEKSFY | QFQHYRAIPG | ||||
| VVEKVKNSEE | QYNKIVIPNE | ESVVIYYKIR | QQLAKLGKEI | EEYIHKPKYC | ||||
| LPFLQPGRLV | KVKNEGDDFG | WGVVVNFSKK | SNVKPNSGEL | DPLYVVEVLL | ||||
| RCSKESLKNS | ATEAAKPAKP | DEKGEMQVVP | VLVHLLSAIS | SVRLYIPKDL | ||||
| RPVDNRQSVL | KSIQEVQKRF | PDGIPLLDPI | DDMGIQDQGL | KKVIQKVEAF | ||||
| EHRMYSHPLH | NDPNLETVYT | LCEKKAQIAI | DIKSAKRELK | KARTVLQMDE | ||||
| LKCRKRVLRR | LGFATSSDVI | EMKGRVACEI | SSADELLLTE | MMFNGLFNDL | ||||
| SAEQATALLS | CFVFQENSSE | MPKLTEQLAG | PLRQMQECAK | RIAKVSAEAK | ||||
| LEIDEETYLS | SFKPHLMDVV | YTWATGATFA | HICKMTDVFE | GSIIRCMRRL | ||||
| EELLRQMCQA | AKAIGNTELE | NKFAEGITKI | KRDIVFAASL | YL |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000039123 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016018 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)".
- ^ "UniProt, P42285" (jezik: engleski). Pristupljeno 20. 10. 2021.
Dopunska literatura
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- Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
- Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
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- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
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- Schilders G, van Dijk E, Pruijn GJ (2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644. PMID 17412707.
- Yang CT, Hindes AE, Hultman KA, Johnson SL (2007). "Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish". PLOS Genet. 3 (6): e88. doi:10.1371/journal.pgen.0030088. PMC 1885281. PMID 17542649.
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