Koristeći komparativnu genomiku, sekvenciranje BAC koji sadrži Smn miša i pretraživanje baze podataka EST, praćeno PCR bibliotekom cDNK mozga miša i ljudskog skeletnih mišića, Scharf et al. (1998) izolirali su cDNK koje kodiraju H4F5 (SERF1) i H4F5REL (SERF2). Analizom sekvence utvrđeno je da SERF2 kodira izvedeni 59-aminokiselinski protein koji ima 69% aminokiselinskog identiteta sa SERF1. SERF2 je visoko nabijeni heliks-okret-heliks protein sa 33% ostataka ili lys ili arg, što sugerira ulogu u vezivanju nukleinskih kiselina.[9]
^Scharf, J. M., Endrizzi, M. G., Wetter, A., Huang, S., Thompson, T. G., Zerres, K., Dietrich, W. F., Wirth, B., Kunkel, L. M. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Nature Genet. 20: 83-86, 1998. PubMed: 9731538
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