SC65
| SC65 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | P3H4 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 617419 MGI: 1913430 HomoloGene: 4713 GeneCards: P3H4 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 17: 41.8 – 41.81 Mb | Chr 11: 100.3 – 100.31 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Sinaptonemni kompleksni protein SC65, znan i kao leprelanoliki protein 4 (LEPREL4) ili jedarčani autoantigen No55, je protein koji je kod ljudi kodiran genom LEPREL4.[5]
Dužina polipeptidnog lanca je 437 aminokiselina, a molekulska težina 50.381.[6].
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MARVAWGLLW | LLLGSAGAQY | EKYSFRGFPP | EDLMPLAAAY | GHALEQYEGE | ||||
| SWRESARYLE | AALRLHRLLR | DSEAFCHANC | SGPAPAAKPD | PDGGRADEWA | ||||
| CELRLFGRVL | ERAACLRRCK | RTLPAFQVPY | PPRQLLRDFQ | SRLPYQYLHY | ||||
| ALFKANRLEK | AVAAAYTFLQ | RNPKHELTAK | YLNYYQGMLD | VADESLTDLE | ||||
| AQPYEAVFLR | AVKLYNSGDF | RSSTEDMERA | LSEYLAVFAR | CLAGCEGAHE | ||||
| QVDFKDFYPA | IADLFAESLQ | CKVDCEANLT | PNVGGYFVDK | FVATMYHYLQ | ||||
| FAYYKLNDVR | QAARSAASYM | LFDPKDSVMQ | QNLVYYRFHR | ARWGLEEEDF | ||||
| QPREEAMLYH | NQTAELRELL | EFTHMYLQSD | DEMELEETEP | PLEPEDALSD | ||||
| AEFEGEGDYE | EGMYADWWQE | PDAKGDEAEA | EPEPELA |
Funkcija
Ovaj nukleolusni protein prvo je okarakteriziran jer je bio autoantigen u slučajevima na intersticijski cistitis. Izgleda da je protein, s predviđenom molekulskom težinom od 50 kDa, lokaliziran u odjeljku čestica u interfazi jedarceta, s distribucijom koja se razlikuje od distribucije nukleolusnog proteina B23. Tokom mitoze povezan je sa hromosomima.[5]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141696 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006931 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SC65 synaptonemal complex protein SC65".
- ^ "UniProt, Q92791". Pristupljeno 11. 6. 2021.
Dopunska literatura
- Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fosså A, Siebert R, Aasheim HC, et al. (2000). "Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer". Br. J. Cancer. 83 (6): 743–9. doi:10.1054/bjoc.2000.1365. PMC 2363543. PMID 10952778.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Ochs RL, Stein TW, Chan EK, et al. (1996). "cDNA cloning and characterization of a novel nucleolar protein". Mol. Biol. Cell. 7 (7): 1015–24. doi:10.1091/mbc.7.7.1015. PMC 275955. PMID 8862517.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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