SASH1
Protein 1 sa SAM i SH3 domenom jest protein koji je kod ljudi kodiran genom SASH1.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.247 aminokiselina, а molekulska težina 136.653 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEDAGAAGPG | PEPEPEPEPE | PEPAPEPEPE | PKPGAGTSEA | FSRLWTDVMG | ||||
| ILDGSLGNID | DLAQQYADYY | NTCFSDVCER | MEELRKRRVS | QDLEVEKPDA | ||||
| SPTSLQLRSQ | IEESLGFCSA | VSTPEVERKN | PLHKSNSEDS | SVGKGDWKKK | ||||
| NKYFWQNFRK | NQKGIMRQTS | KGEDVGYVAS | EITMSDEERI | QLMMMVKEKM | ||||
| ITIEEALARL | KEYEAQHRQS | AALDPADWPD | GSYPTFDGSS | NCNSREQSDD | ||||
| ETEESVKFKR | LHKLVNSTRR | VRKKLIRVEE | MKKPSTEGGE | EHVFENSPVL | ||||
| DERSALYSGV | HKKPLFFDGS | PEKPPEDDSD | SLTTSPSSSS | LDTWGAGRKL | ||||
| VKTFSKGESR | GLIKPPKKMG | TFFSYPEEEK | AQKVSRSLTE | GEMKKGLGSL | ||||
| SHGRTCSFGG | FDLTNRSLHV | GSNNSDPMGK | EGDFVYKEVI | KSPTASRISL | ||||
| GKKVKSVKET | MRKRMSKKYS | SSVSEQDSGL | DGMPGSPPPS | QPDPEHLDKP | ||||
| KLKAGGSVES | LRSSLSGQSS | MSGQTVSTTD | SSTSNRESVK | SEDGDDEEPP | ||||
| YRGPFCGRAR | VHTDFTPSPY | DTDSLKLKKG | DIIDIISKPP | MGTWMGLLNN | ||||
| KVGTFKFIYV | DVLSEDEEKP | KRPTRRRRKG | RPPQPKSVED | LLDRINLKEH | ||||
| MPTFLFNGYE | DLDTFKLLEE | EDLDELNIRD | PEHRAVLLTA | VELLQEYDSN | ||||
| SDQSGSQEKL | LVDSQGLSGC | SPRDSGCYES | SENLENGKTR | KASLLSAKSS | ||||
| TEPSLKSFSR | NQLGNYPTLP | LMKSGDALKQ | GQEEGRLGGG | LAPDTSKSCD | ||||
| PPGVTGLNKN | RRSLPVSICR | SCETLEGPQT | VDTWPRSHSL | DDLQVEPGAE | ||||
| QDVPTEVTEP | PPQIVPEVPQ | KTTASSTKAQ | PLEQDSAVDN | ALLLTQSKRF | ||||
| SEPQKLTTKK | LEGSIAASGR | GLSPPQCLPR | NYDAQPPGAK | HGLARTPLEG | ||||
| HRKGHEFEGT | HHPLGTKEGV | DAEQRMQPKI | PSQPPPVPAK | KSRERLANGL | ||||
| HPVPMGPSGA | LPSPDAPCLP | VKRGSPASPT | SPSDCPPALA | PRPLSGQAPG | ||||
| SPPSTRPPPW | LSELPENTSL | QEHGVKLGPA | LTRKVSCARG | VDLETLTENK | ||||
| LHAEGIDLTE | EPYSDKHGRC | GIPEALVQRY | AEDLDQPERD | VAANMDQIRV | ||||
| KQLRKQHRMA | IPSGGLTEIC | RKPVSPGCIS | SVSDWLISIG | LPMYAGTLST | ||||
| AGFSTLSQVP | SLSHTCLQEA | GITEERHIRK | LLSAARLFKL | PPGPEAM |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- ^ Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (maj 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.
- ^ "Entrez Gene: SASH1 SAM and SH3 domain containing 1".
- ^ "UniProt, O94885" (jezik: engleski). Pristupljeno 10. 10. 2021.
Dopunska literatura
- Rimkus C, Martini M, Friederichs J, et al. (2007). "Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer". Br. J. Cancer. 95 (10): 1419–23. doi:10.1038/sj.bjc.6603452. PMC 2360597. PMID 17088907.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
- Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vanjski linkovi
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