RGCC
Regulator ćelijskog ciklusa RGCC (RGCC), znan i kao odgovorni gen za protrinski komplement 3 (RGC-32) je protein koji je kod ljudi kodiran genom RGCC.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 137 aminokiselina, a molekulska težina 14.559 Da.[8].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MKPPAAQGSP | AAAAAAAPAL | DSAAAEDLSD | ALCEFDAVLA | DFASPFHERH | ||||
| FHYEEHLERM | KRRSSASVSD | SSGFSDSESA | DSLYRNSFSF | SDEKLNSPTD | ||||
| STPALLSATV | TPQKAKLGDT | KELEAFIADL | DKTLASM |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Funkcija
Smatra se da ovaj gen regulira napredovanje ćelijskog ciklusa. Izaziva ga p53, kao odgovor na oštećenje DNK, ili subrazgrađujuće nivoe proteinskog sistema komplementa koji rezultiraju aktivacijom ćelijskog ciklusa. Kodirani protein se lokalizira u citoplazmi, tokom interfaze i u centrosomima tokom mitoza. Protein formira kompleks s polo-lika kinaza 1. Protein se također translocira u jedro, kao odgovor na liječenje proteinima komplementnog sistema, a može se povezati i povećati aktivnost kinaze ciklusa ćelijske diobe dva proteina. U različitim testovima i tipovima ćelija pokazalo se da prekomjerna ekspresija ovog proteina aktivira ili suzbija napredovanje ćelijskog ciklusa.[7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102760 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022018 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J (Feb 2007). "RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest". Oncogene. 26 (8): 1110–21. doi:10.1038/sj.onc.1210148. PMID 17146433.
- ^ Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY (Mar 2009). "RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells". J Biol Chem. 284 (14): 9426–32. doi:10.1074/jbc.M900039200. PMC 2666595. PMID 19158077.
- ^ a b "Entrez Gene: RGC32 response gene to complement 32".
- ^ "UniProt, Q9H4X1". Pristupljeno 5. 8. 2021.
Dopunska literatura
- Fosbrink M, Niculescu F, Rus H (2005). "The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription". Immunol. Res. 31 (1): 37–46. doi:10.1385/IR:31:1:37. PMID 15591621.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Badea TC, Niculescu FI, Soane L, et al. (1998). "Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes". J. Biol. Chem. 273 (41): 26977–81. doi:10.1074/jbc.273.41.26977. PMID 9756947.
- Badea T, Niculescu F, Soane L, et al. (2002). "RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase". J. Biol. Chem. 277 (1): 502–8. doi:10.1074/jbc.M109354200. PMID 11687586.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Fosbrink M, Cudrici C, Niculescu F, et al. (2005). "Overexpression of RGC-32 in colon cancer and other tumors". Exp. Mol. Pathol. 78 (2): 116–22. doi:10.1016/j.yexmp.2004.11.001. PMID 15713436.
- Tanaka T, Takada H, Nomura A, et al. (2005). "Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome". Clin. Exp. Immunol. 140 (3): 524–31. doi:10.1111/j.1365-2249.2005.02805.x. PMC 1809394. PMID 15932515.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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