RERG

RERG
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2ATV

Identifikatori
AliasiRERG
Vanjski ID-jeviOMIM: 612664 MGI: 2665139 HomoloGene: 50026 GeneCards: RERG
EC broj3.6.5.2
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za RERG
Genomska lokacija za RERG
Bend12p12.3Početak15,107,783 bp[1]
Kraj15,348,675 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za RERG
Genomska lokacija za RERG
Bend6|6 G1Početak137,031,823 bp[2]
Kraj137,147,495 bp[2]
Ontologija gena
Molekularna funkcija• nucleotide binding
• GTP binding
• GDP binding
• estrogen receptor binding
• GO:0006184 GTPase activity
Ćelijska komponenta• citosol
• jedro
• membrana
• citoplazma
• ćelijska membrana
Biološki proces• negative regulation of cell population proliferation
• response to hormone
• negative regulation of cell growth
• GO:0072468 Transdukcija signala
• small GTPase mediated signal transduction
• Ras protein signal transduction
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

85004

232441

Ensembl

ENSG00000134533

ENSMUSG00000030222

UniProt

Q96A58

Q8R367

RefSeq (mRNK)

NM_001190726
NM_032918

NM_001164212
NM_001164214
NM_181988

RefSeq (bjelančevina)

NP_001177655
NP_116307

NP_001157684
NP_001157686
NP_871788

Lokacija (UCSC)Chr 12: 15.11 – 15.35 MbChr 6: 137.03 – 137.15 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

RAS-oliki, estrogen-regulirani inhibitor rasta je protein koji je kod ljudi kodiran genom RERG.[5]

RERG, član superporodice RAS GTPaza, inhibira ćelijsku proliferaciju i formiranje tumora (Finlin et al., 2001 PubMed 11533059]).(prema OMIM, mart 2009).

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 199 aminokiselina, a molekulska težina 22.608 Da.[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin

P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

1020304050
MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATID
DEVVSMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKN
ILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSAC
TGEGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134533 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030222 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RAS-like, estrogen-regulated, growth inhibitor". Pristupljeno 9. 11. 2012.
  6. ^ "UniProt, Q96A58". Pristupljeno 14. 8. 2021.

Vanjski linkovi

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ras-related and estrogen-regulated growth inhibitor (RERG)

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