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REG4
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2KV3
Identifikatori
Aliasi	REG4
Vanjski ID-jevi	OMIM: 609846 MGI: 1914959 HomoloGene: 41671 GeneCards: REG4
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	119,811,580 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	98,144,064 bp
Ontologija gena
Molekularna funkcija	• calcium ion binding; • heparin binding; • mannan binding; • carbohydrate binding; • transmembrane signaling receptor activity;
Ćelijska komponenta	• citoplazma; • extracellular region;
Biološki proces	• response to bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	83998
	67709
	ENSG00000134193
	ENSMUSG00000027876
	Q9BYZ8
	Q9D8G5
	NM_032044; NM_001159352; NM_001159353
	NM_026328
	NP_001152824; NP_001152825; NP_114433
	NP_080604
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Regeneracijski protein 4 izveden iz otočića jest protein koji je kod ljudi kodiran genom REG4 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 158 aminokiselina, a molekulska težina Da. 18 230^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASRSMRLLL	LLSCLAKTGV	LGDIIMRPSC	APGWFYHKSN	CYGYFRKLRN
WSDAELECQS	YGNGAHLASI	LSLKEASTIA	EYISGYQRSQ	PIWIGLHDPQ
KRQQWQWIDG	AMYLYRSWSG	KSMGGNKHCA	EMSSNNNFLT	WSSNECNKRQ
HFLCKYRP

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134193 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027876 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID 11311942.
^ Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032.
^ "Entrez Gene: REG4 regenerating islet-derived family, member 4".
^ "UniProt, Q9BYZ8" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kämäräinen M, Heiskala K, Knuutila S, et al. (2003). "RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa". Am. J. Pathol. 163 (1): 11–20. doi:10.1016/S0002-9440(10)63625-5. PMC 1868159. PMID 12819006.
Zhang Y, Lai M, Lv B, et al. (2003). "Overexpression of Reg IV in colorectal adenoma". Cancer Lett. 200 (1): 69–76. doi:10.1016/S0304-3835(03)00460-9. PMID 14550954.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gu Z, Rubin MA, Yang Y, et al. (2005). "Reg IV: a promising marker of hormone refractory metastatic prostate cancer". Clin. Cancer Res. 11 (6): 2237–43. doi:10.1158/1078-0432.CCR-04-0356. PMID 15788672.
Bishnupuri KS, Luo Q, Murmu N, et al. (2006). "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas". Gastroenterology. 130 (1): 137–49. doi:10.1053/j.gastro.2005.10.001. PMID 16401477.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Takehara A, Eguchi H, Ohigashi H, et al. (2006). "Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4". Cancer Sci. 97 (11): 1191–7. doi:10.1111/j.1349-7006.2006.00297.x. PMID 16918991.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134193 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027876 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11311942-5] Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID 11311942.

[pmid12455032-6] Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032.

[entrez-7] "Entrez Gene: REG4 regenerating islet-derived family, member 4".

[UniProt-8] "UniProt, Q9BYZ8" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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REG4

Aminokiselinska sekvenca

Reference

Dopunska literatura

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