Homolog 2 prunskog proteina je protein koji je kod ljudi kodiran genom PRUNE2 .[ 5] [ 6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 3.088 aminokiselina , а molekulska težina 340.635 Da .[ 7]
10 20 30 40 50 MEEFLQRAKS KLNRSKRLEK VHVVIGPKSC DLDSLISTFT YAYFLDKVSP PGVLCLPVLN IPRTEFNYFT ETRFILEELN ISESFHIFRD EINLHQLNDE GKLSITLVGS SVLASEDKTL ESAVVKVINP VEQSDANVEF RESSSSLVLK EILQEAPELI TEQLAHRLRG SILFKWMTME SEKISEKQEE ILSILEEKFP NLPPREDIIN VLQETQFSAQ GLSIEQTMLK DLKELSDGEI KVAISTVSMN LENCLFHSNI TSDLKAFTDK FGFDVLILFS SYLSEEQQPR RQIAVYSENM ELCSQICCEL EECQNPCLEL EPFDCGCDEI LVYQQEDPSV TCDQVVLVVK EVINRRCPEM VSNSRTSSTE AVAGSAPLSQ GSSGIMELYG SDIEPQPSSV NFIENPPDLN DSNQAQVDAN VDLVSPDSGL ATIRSSRSSK ESSVFLSDDS PVGEGAGPHH TLLPGLDSYS PIPEGAVAEE HAWSGEHGEH FDLFNFDPAP MASGQSQQSS HSADYSPADD FFPNSDLSEG QLPAGPEGLD GMGTNMSNYS SSSLLSGAGK DSLVEHDEEF VQRQDSPRDN SERNLSLTDF VGDESPSPER LKNTGKRIPP TPMNSLVESS PSTEEPASLY TEDMTQKATD TGHMGPPQTH ARCSSWWGGL EIDSKNIADA WSSSEQESVF QSPESWKEHK PSSIDRRASD SVFQPKSLEF TKSGPWESEF GQPELGSNDI QDKNEESLPF QNLPMEKSPL PNTSPQGTNH LIEDFASLWH SGRSPTAMPE PWGNPTDDGE PAAVAPFPAW SAFGKEDHDE ALKNTWNLHP TSSKTPSVRD PNEWAMAKSG FAFSSSELLD NSPSEINNEA APEIWGKKNN DSRDHIFAPG NPSSDLDHTW TNSKPPKEDQ NGLVDPKTRG KVYEKVDSWN LFEENMKKGG SDVLVPWEDS FLSYKCSDYS ASNLGEDSVP SPLDTNYSTS DSYTSPTFAG DEKETEHKPF AKEEGFESKD GNSTAEETDI PPQSLQQSSR NRISSGPGNL DMWASPHTDN SSEINTTHNL DENELKTEHT DGKNISMEDD VGESSQSSYD DPSMMQLYNE TNRQLTLLHS STNSRQTAPD SLDLWNRVIL EDTQSTATIS DMDNDLDWDD CSGGAAIPSD GQTEGYMAEG SEPETRFTVR QLEPWGLEYQ EANQVDWELP ASDEHTKDSA PSEHHTLNEK SGQLIANSIW DSVMRDKDMS SFMLPGSSHI TDSEQRELPP EIPSHSANVK DTHSPDAPAA SGTSESEALI SHLDKQDTER ETLQSDAASL ATRLENPGYF PHPDPWKGHG DGQSESEKEA QGATDRGHLD EEEVIASGVE NASGISEKGQ SDQELSSLVA SEHQEICIKS GKISSLAVTF SPQTEEPEEV LEYEEGSYNL DSRDVQTGMS ADNLQPKDTH EKHLMSQRNS GETTETSDGM NFTKYVSVPE KDLEKTEECN FLEPENVGGG PPHRVPRSLD FGDVPIDSDV HVSSTCSEIT KNLDVKGSEN SLPGAGSSGN FDRDTISSEY THSSASSPEL NDSSVALSSW GQQPSSGYQE ENQGNWSEQN HQESELITTD GQVEIVTKVK DLEKNRINEF EKSFDRKTPT FLEIWNDSVD GDSFSSLSSP ETGKYSEHSG THQESNLIAS YQEKNEHDIS ATVQPEDARV ISTSSGSDDD SVGGEESIEE EIQVANCHVA EDESRAWDSL NESNKFLVTA DPKSENIYDY LDSSEPAENE NKSNPFCDNQ QSSPDPWTFS PLTETEMQIT AVEKEKRSSP ETGTTGDVAW QISPKASFPK NEDNSQLEML GFSADSTEWW KASPQEGRLI ESPFERELSD SSGVLEINSS VHQNASPWGV PVQGDIEPVE THYTNPFSDN HQSPFLEGNG KNSHEQLWNI QPRQPDPDAD KFSQLVKLDQ IKEKDSREQT FVSAAGDELT PETPTQEQCQ DTMLPVCDHP DTAFTHAEEN SCVTSNVSTN EGQETNQWEQ EKSYLGEMTN SSIATENFPA VSSPTQLIMK PGSEWDGSTP SEDSRGTFVP DILHGNFQEG GQLASAAPDL WIDAKKPFSL KADGENPDIL THCEHDSNSQ ASDSPDICHD SEAKQETEKH LSACMGPEVE SSELCLTEPE IDEEPIYEPG REFVPSNAEL DSENATVLPP IGYQADIKGS SQPASHKGSP EPSEINGDNS TGLQVSEKGA SPDMAPILEP VDRRIPRIEN VATSIFVTHQ EPTPEGDGSW ISDSFSPESQ PGARALFDGD PHLSTENPAL VPDALLASDT CLDISEAAFD HSFSDASGLN TSTGTIDDMS KLTLSEGHPE TPVDGDLGKQ DICSSEASWG DFEYDVMGQN IDEDLLREPE HFLYGGDPPL EEDSLKQSLA PYTPPFDLSY LTEPAQSAET IEEAGSPEDE SLGCRAAEIV LSALPDRRSE GNQAETKNRL PGSQLAVLHI REDPESVYLP VGAGSNILSP SNVDWEVETD NSDLPAGGDI GPPNGASKEI SELEEEKTIP TKEPEQIKSE YKEERCTEKN EDRHALHMDY ILVNREENSH SKPETCEERE SIAELELYVG SKETGLQGTQ LASFPDTCQP ASLNERKGLS AEKMSSKSDT RSSFESPAQD QSWMFLGHSE VGDPSLDARD SGPGWSGKTV EPFSELGLGE GPQLQILEEM KPLESLALEE ASGPVSQSQK SKSRGRAGPD AVTLQAVTHD NEWEMLSPQP VQKNMIPDTE MEEETEFLEL GTRISRPNGL LSEDVGMDIP FEEGVLSPSA ADMRPEPPNS LDLNDTHPRR IKLTAPNINL SLDQSEGSIL SDDNLDSPDE IDINVDELDT PDEADSFEYT GHDPTANKDS GQESESIPEY TAEEEREDNR LWRTVVIGEQ EQRIDMKVIE PYRRVISHGG YYGDGLNAII VFAACFLPDS SRADYHYVME NLFLYVISTL ELMVAEDYMI VYLNGATPRR RMPGLGWMKK CYQMIDRRLR KNLKSFIIVH PSWFIRTILA VTRPFISSKF SSKIKYVNSL SELSGLIPMD CIHIPESIIK LDEELREASE AAKTSCLYND PEMSSMEKDI DLKLKEKP
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000106772 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039126 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas" . Oncogene . 25 (13): 1931–42. doi :10.1038/sj.onc.1209225 PMID 16288218 . ^ "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)" .^ "UniProt, Q8WUY3" . Pristupljeno 11. 9. 2021 .
Dopunska literatura
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