PRSS16
| PRSS16 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | PRSS16 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 607169 MGI: 1859181 HomoloGene: 38106 GeneCards: PRSS16 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 6: 27.25 – 27.26 Mb | Chr 13: 22.19 – 22.19 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Timus-specifična serin-proteaza jest enzim koji je kod ljudi kodiran genom PRSS16.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 514 aminokiselina, а molekulska težina 55.049 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAVWLAQWLG | PLLLVSLWGL | LAPASLLRRL | GEHIQQFQES | SAQGLGLSLG | ||||
| PGAAALPKVG | WLEQLLDPFN | VSDRRSFLQR | YWVNDQHWVG | QDGPIFLHLG | ||||
| GEGSLGPGSV | MRGHPAALAP | AWGALVISLE | HRFYGLSIPA | GGLEMAQLRF | ||||
| LSSRLALADV | VSARLALSRL | FNISSSSPWI | CFGGSYAGSL | AAWARLKFPH | ||||
| LIFASVASSA | PVRAVLDFSE | YNDVVSRSLM | STAIGGSLEC | RAAVSVAFAE | ||||
| VERRLRSGGA | AQAALRTELS | ACGPLGRAEN | QAELLGALQA | LVGGVVQYDG | ||||
| QTGAPLSVRQ | LCGLLLGGGG | NRSHSTPYCG | LRRAVQIVLH | SLGQKCLSFS | ||||
| RAETVAQLRS | TEPQLSGVGD | RQWLYQTCTE | FGFYVTCENP | RCPFSQLPAL | ||||
| PSQLDLCEQV | FGLSALSVAQ | AVAQTNSYYG | GQTPGANKVL | FVNGDTDPWH | ||||
| VLSVTQALGS | SESTLLIRTG | SHCLDMAPER | PSDSPSLRLG | RQNIFQQLQT | ||||
| WLKLAKESQI | KGEV |
Funkcija
Ovaj gen kodira serin-proteazu eksprimiranu isključivo u timusu. Smatra se da ima ulogu u alternativnom putu prezentacije antigena koji koriste epitelne ćelije kore timusa, tokom pozitivne selekcije T-ćelija.
Gen se nalazi u velikoj grupi histonskih gena na hromosomu 6, u blizini glavnog kompleksa histokompatibilnosti (MHC) klase I. Opisana je druga varijanta transkripta, ali nije utvrđena njena puna dužina.[6]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112812 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006179 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
- ^ a b "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".
- ^ "UniProt, Q9NQE7" (jezik: engleski). Pristupljeno 4. 10. 2021.
Dopunska literatura
- Lie BA, Viken MK, Akselsen HE, et al. (2007). "Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease". Hum. Immunol. 68 (7): 592–8. doi:10.1016/j.humimm.2007.03.009. PMID 17584581.
- Luther C, Wienhold W, Oehlmann R, et al. (2005). "Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus". Genes Immun. 6 (1): 1–7. doi:10.1038/sj.gene.6364142. PMID 15592422.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Lie BA, Akselsen HE, Bowlus CL, et al. (2003). "Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases". Genes Immun. 3 (5): 306–12. doi:10.1038/sj.gene.6363858. PMID 12140752.
- Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.
Vanjski linkovi
- PRSS16 lokacija ljudskog genoma UCSC Genome Browser.
PRSS16 detalji ljudskog genoma u UCSC Genome Browser.
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