PHF2

PHF2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS

Identifikatori
AliasiPHF2
Vanjski ID-jeviOMIM: 604351 MGI: 1338034 HomoloGene: 3934 GeneCards: PHF2
Lokacija gena (čovjek)
Hromosom 9 (čovjek)
Hrom.Hromosom 9 (čovjek)[1]
Hromosom 9 (čovjek)
Genomska lokacija za PHF2
Genomska lokacija za PHF2
Bend9q22.31Početak93,576,584 bp[1]
Kraj93,679,587 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za PHF2
Genomska lokacija za PHF2
Bend13 A5|13 24.96 cMPočetak48,955,226 bp[2]
Kraj49,024,595 bp[2]
Ontologija gena
Molekularna funkcija• iron ion binding
• histone H3-methyl-lysine-9 demethylase activity
• GO:0001105 transcription coactivator activity
• dioxygenase activity
• vezivanje iona metala
• methylated histone binding
• GO:0001948, GO:0016582 vezivanje za proteine
• oxidoreductase activity
• histone demethylase activity
• vezivanje iona cinka
Ćelijska komponenta• nukleoplazma
• hromosom
• Jedarce
• Primarno suženje
• kinetohor
• jedro
Biološki proces• GO:0009373 regulation of transcription, DNA-templated
• histone H3-K9 demethylation
• protein demethylation
• transcription, DNA-templated
• negative regulation of ribosomal DNA heterochromatin assembly
• liver development
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

5253

18676

Ensembl

ENSG00000197724

ENSMUSG00000038025

UniProt

O75151

Q9WTU0

RefSeq (mRNK)

NM_005392
NM_024517

NM_011078

RefSeq (bjelančevina)

NP_005383

NP_035208

Lokacija (UCSC)Chr 9: 93.58 – 93.68 MbChr 13: 48.96 – 49.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein PHD-prsta 2 je protein koji je kod ljudi kodiran genom PHF2.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.096 aminokiselina, а molekulska težina Da. 120 775[6]

1020304050
MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHC
PNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPS
AEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVE
NYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDT
RMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHI
DSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVD
KCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYE
VERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAK
ILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVR
PEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMP
KPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEA
HTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSE
AKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKAL
RPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAP
KRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRN
ARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLS
MANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAA
KNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSD
DAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSK
KKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTAS
SQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFL
TQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL

Funkcija

Ovaj gen kodira protein koji sadrži prst poput cinkovog prsta PHD (biljni homeodomen), za razliku od drugih klasa motiva cinkovog prsta, te hidrofobni i visoko konzervirani domen . PHD prst prikazuje tipski aranžman Cys4–His–Cys3. Smatra se da geni PHD-prstiju pripadaju raznolikoj skupini transkripcijskih regulatora koji mogu uticati na ekspresiju gena eukariota, utičući na strukturu hromatina.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PHD finger protein 2". Pristupljeno 9. 4. 2016.
  6. ^ "UniProt, O75151". Pristupljeno 10. 9. 2021.

Dopunska literatura

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