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PERP
Identifikatori
Aliasi	PERP
Vanjski ID-jevi	OMIM: 609301 MGI: 1929938 HomoloGene: 11098 GeneCards: PERP
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	138,107,419 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	18,732,821 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	64065
	64058
	ENSG00000112378
	ENSMUSG00000019851
	Q96FX8
	Q9JK95
	NM_022121
	NM_022032
	NP_071404
	NP_071315
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

PMP-22 apoptozno srodni efektor p53 jest plazmamembranski protein koji je kod ljudi kodiran genom PERP.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 193 aminokiseline, а molekulska težina 21.386 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MIRCGLACER	CRWILPLLLL	SAIAFDIIAL	AGRGWLQSSD	HGQTSSLWWK
CSQEGGGSGS	YEEGCQSLME	YAWGRAAAAM	LFCGFIILVI	CFILSFFALC
GPQMLVFLRV	IGGLLALAAV	FQIISLVIYP	VKYTQTFTLH	ANPAVTYIYN
WAYGFGWAAT	IILIGCAFFF	CCLPNYEDDL	LGNAKPRYFY	TSA

Funkcija

PERP je direktna transkripcijska meta p53, ali se njegova transkripcija može regulirati i drugim faktorima transkripcije.^[8]

PERP je važan za razvoj kože, a gubitak PERP-a povezan je s razvojem i progresijom nekoliko tipova ljudskih kancera.^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112378 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019851 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res. 20 (5A): 2801–2809. PMID 11062687.
^ "Entrez Gene: PERP PERP, TP53 apoptosis effector".
^ "UniProt, Q96FX8" (jezik: engleski). Pristupljeno 10. 10. 2021.
^ ^a ^b Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP". Biochim Biophys Acta Rev Cancer. 1874 (1): 188393. doi:10.1016/j.bbcan.2020.188393. PMID 32679166. S2CID 220631324.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Attardi LD, Reczek EE, Cosmas C, et al. (2000). "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family". Genes Dev. 14 (6): 704–718. PMC 316461. PMID 10733530.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–664. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Ihrie RA, Attardi LD (2004). "Perp-etrating p53-dependent apoptosis". Cell Cycle. 3 (3): 267–269. doi:10.4161/cc.3.3.722. PMID 14726658.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112378 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019851 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11062687-5] Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res. 20 (5A): 2801–2809. PMID 11062687.

[entrez-6] "Entrez Gene: PERP PERP, TP53 apoptosis effector".

[UniProt-7] "UniProt, Q96FX8" (jezik: engleski). Pristupljeno 10. 10. 2021.

[pmid32679166-8] Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP". Biochim Biophys Acta Rev Cancer. 1874 (1): 188393. doi:10.1016/j.bbcan.2020.188393. PMID 32679166. S2CID 220631324.

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PERP

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

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