PDCD7
| PDCD7 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | PDCD7 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 608138 MGI: 1859170 HomoloGene: 4170 GeneCards: PDCD7 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) |
| ||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 15: 65.12 – 65.13 Mb | Chr 9: 65.25 – 65.27 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
Protein 7 programirane ćelijske smrti je protein koji je kod ljudi kodiran genom PDCD7.[5][6]
Ovaj gen kodira protein slične sekvence mišjeg proteina koji je izvorno identificiran u embrionskim matičnim ćelijaka. U mišjim T-ćelijskim linijama ovaj protein povezan je sa glukokortikoidima i apoptotskim putevima izazvanim staurinom i povezan sa keramid omposredovanom signalizacijom. Ova zapažanja sugeriraju da je ovaj genski proizvod uključen u specifične apoptozne procese u T-ćelijama.[6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 485 aminokiselina, a molekulska težina 54.700 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MALPPFFGQG | RPGPPPPQPP | PPAPFGCPPP | PLPSPAFPPP | LPQRPGPFPG | ||||
| ASAPFLQPPL | ALQPRASAEA | SRGGGGAGAF | YPVPPPPLPP | PPPQCRPFPG | ||||
| TDAGERPRPP | PPGPGPPWSP | RWPEAPPPPA | DVLGDAALQR | LRDRQWLEAV | ||||
| FGTPRRAGCP | VPQRTHAGPS | LGEVRARLLR | ALRLVRRLRG | LSQALREAEA | ||||
| DGAAWVLLYS | QTAPLRAELA | ERLQPLTQAA | YVGEARRRLE | RVRRRRLRLR | ||||
| ERAREREAER | EAEAARAVER | EQEIDRWRVK | CVQEVEEKKR | EQELKAAADG | ||||
| VLSEVRKKQA | DTKRMVDILR | ALEKLRKLRK | EAAARKGVCP | PASADETFTH | ||||
| HLQRLRKLIK | KRSELYEAEE | RALRVMLEGE | QEEERKRELE | KKQRKEKEKI | ||||
| LLQKREIESK | LFGDPDEFPL | AHLLEPFRQY | YLQAEHSLPA | LIQIRHDWDQ | ||||
| YLVPSDHPKG | NFVPQGWVLP | PLPSNDIWAT | AVKLH |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000090470 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041837 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells". Nucleic Acids Res. 27 (6): 1524–30. doi:10.1093/nar/27.6.1524. PMC 148348. PMID 10037816.
- ^ a b "Entrez Gene: PDCD7 programmed cell death 7".
- ^ "UniProt, Q8N8D1". Pristupljeno 16. 7. 2021.
Dopunska literatura
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vanjski linkovi
- PDCD7 lokacija ljudskog genoma UCSC Genome Browser.
PDCD7 detalji ljudskog genoma u UCSC Genome Browser.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.