PCYOX1

PCYOX1
Identifikatori
AliasiPCYOX1
Vanjski ID-jeviOMIM: 610995 MGI: 1914131 HomoloGene: 9458 GeneCards: PCYOX1
EC broj1.8.3.5
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za PCYOX1
Genomska lokacija za PCYOX1
Bend2p13.3Početak70,257,386 bp[1]
Kraj70,281,185 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za PCYOX1
Genomska lokacija za PCYOX1
Bend6|6 D1Početak86,362,988 bp[2]
Kraj86,374,136 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• oxidoreductase activity
• oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
• prenylcysteine oxidase activity
Ćelijska komponenta• ćelijska membrana
• Egzosom
• vacuolar membrane
• very-low-density lipoprotein particle
• Lizozom
Biološki proces• prenylcysteine metabolic process
• chloride transport
• chloride transmembrane transport
• prenylcysteine catabolic process
• prenylated protein catabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

51449

66881

Ensembl

ENSG00000116005

ENSMUSG00000029998

UniProt

Q9UHG3

Q9CQF9

RefSeq (mRNK)

NM_016297

NM_025823
NM_001355687

RefSeq (bjelančevina)

NP_057381

NP_080099
NP_001342616

Lokacija (UCSC)Chr 2: 70.26 – 70.28 MbChr 6: 86.36 – 86.37 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

PCBP1 antisens RNK 1 jest protein koji je kod ljudi kodiran genom PCBP1-AS1 sa hromosoma 2.[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 505 aminokiselina, a molekulska težina 56.640 Da.[6]

1020304050
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAA
YYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMK
RFVKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSL
RMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLL
ETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAV
EGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIG
TETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKG
ELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTD
GTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIIL
HDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEK
LKTEL

Funkcija

U jednom istraživanju iz 2017. , identificirani su skupovi funkcionalno povezanih dugolančanih nekodirajućih RNK (lncRNA) i iRNK i procijenivan značaj lncRNK u mreži lncRNK-iRNK. Sroveli su ponderiranu analizu mreže koekspresije gena i analizu obogaćivanja da identifciraju funkcionalne module koekspresiranih lncRNK i iRNK u monojedarnim ćelijama periferne krvi 43 žene. Identificirali su sedam modula i pronašli lokus lncRNK u svakom modulu. Četiri od sedam modula imala su značajna obogaćenja genske ontologije. Neke od čvorišnih lncRNK (npr. SSX8, UCA1, HOXA-AS2, STARD4-AS1 i PCBP1-AS1) imaju poznate funkcije povezane s bolestima kao što su kanceri. U zaključku se navodi da su pokazali da lncRNK mogu imati važnu ulogu u modulima koekspresije lncRNK-iRNK.[7]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116005 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029998 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PCBP1 antisense RNA 1". Pristupljeno 30. 7. 2018.
  6. ^ "UniProt, Q9UHG3" (jezik: engleski). Pristupljeno 14. 11. 2021.
  7. ^ Xing-Bo Mo, Long-Fei Wu, Xiao-Wei Zhu , Wei Xia , Lan Wang , Pei He, Peng-Fei Bing, Xin Lu, Yong-Hong Zhang , Fei-Yan Deng , Shu-Feng Lei (2017): Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells.Epigenomics, 9(7): 943-954; pmid: 28621149; doi: 10.2217/epi-2016-0178

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