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OLFML3
Identifikatori
Aliasi	OLFML3
Vanjski ID-jevi	OMIM: 610088 MGI: 1914877 HomoloGene: 10613 GeneCards: OLFML3
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	114,035,572 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	103,645,317 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	56944
	99543
	ENSG00000116774
	ENSMUSG00000027848
	Q9NRN5
	Q8BK62
	NM_020190; NM_001286352; NM_001286353
	NM_133859
	NP_001273281; NP_001273282; NP_064575; NP_064575.1
	NP_598620
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Olfaktomedinoliki protein 3 jest protein koji je kod ljudi kodiran genom OLFML3 sa hromosoma 1.^[5] Pokazalo se da djeluje kao proangiongeni faktor u mikrookruženju tumora, oslobađajući ga endotelnih ćelija i pericita.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 406 aminokiselina, a molekulska težina 46.010 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGPSTPLLIL	FLLSWSGPLQ	GQQHHLVEYM	ERRLAALEER	LAQCQDQSSR
HAAELRDFKN	KMLPLLEVAE	KEREALRTEA	DTISGRVDRL	EREVDYLETQ
NPALPCVEFD	EKVTGGPGTK	GKGRRNEKYD	MVTDCGYTIS	QVRSMKILKR
FGGPAGLWTK	DPLGQTEKIY	VLDGTQNDTA	FVFPRLRDFT	LAMAARKASR
VRVPFPWVGT	GQLVYGGFLY	FARRPPGRPG	GGGEMENTLQ	LIKFHLANRT
VVDSSVFPAE	GLIPPYGLTA	DTYIDLAADE	EGLWAVYATR	EDDRHLCLAK
LDPQTLDTEQ	QWDTPCPREN	AEAAFVICGT	LYVVYNTRPA	SRARIQCSFD
ASGTLTPERA	ALPYFPRRYG	AHASLRYNPR	ERQLYAWDDG	YQIVYKLEMR
KKEEEV

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116774 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027848 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OLFML3 olfactomedin-like 3".
^ Miljkovic-Licina, M.; Hammel, P.; Garrido-Urbani, S.; Lee, B. P.- L.; Meguenani, M.; Chaabane, C.; Bochaton-Piallat, M.-L.; Imhof, B. A. (20. 9. 2012). "Targeting Olfactomedin-like 3 Inhibits Tumor Growth by Impairing Angiogenesis and Pericyte Coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi:10.1158/1535-7163.MCT-12-0245. PMID 23002094.
^ "UniProt, Q9NRN5" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zeng LC, Liu F, Zhang X, et al. (2004). "hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis". FEBS Lett. 571 (1–3): 74–80. doi:10.1016/j.febslet.2004.06.059. PMID 15280020.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116774 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027848 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OLFML3 olfactomedin-like 3".

[6] Miljkovic-Licina, M.; Hammel, P.; Garrido-Urbani, S.; Lee, B. P.- L.; Meguenani, M.; Chaabane, C.; Bochaton-Piallat, M.-L.; Imhof, B. A. (20. 9. 2012). "Targeting Olfactomedin-like 3 Inhibits Tumor Growth by Impairing Angiogenesis and Pericyte Coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi:10.1158/1535-7163.MCT-12-0245. PMID 23002094.

[UniProt-7] "UniProt, Q9NRN5" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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OLFML3

Aminokiselinska sekvenca

Reference

Dopunska literatura

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