NUPL1
Nukleoporin p58/p45 je protein koji je kod ljudi kodiran genom NUPL1.[5][6]
Ovaj gen kodira člana porodice nukleoporina koji dijeli 87% identiteta sekvence s nukleoporinom p58 pacova. Protein je lokaliziran na jedarnom rubu i sastavni je dio kompleksa jedarnih pora (NPC).
Sve molekule koji ulaze ili izlaze iz jedra difundiraju ili se aktivno transportiraju pomoću NPC -a. Okarakterizirane su alternativne transkripcijske varijante, koje kodiraju različite izoforme.[6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 599 aminokiselina, a molekulska težina 60.897 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSTGFSFGSG | TLGSTTVAAG | GTSTGGVFSF | GTGASSNPSV | GLNFGNLGST | ||||
| STPATTSAPS | SGFGTGLFGS | KPATGFTLGG | TNTGIATTIT | TGLTLGTPAT | ||||
| TSAATTGFSL | GFNKPAASAT | PFALPITSTS | ASGLTLSSAL | TSTPAASTGF | ||||
| TLNNLGGTTA | TTTTASTGLS | LGGALAGLGG | SLFQSTNTGT | SGLGQNALGL | ||||
| TLGTTAATST | AGNEGLGGID | FSSSSDKKSD | KTGTRPEDSK | ALKDENLPPV | ||||
| ICQDVENLQK | FVKEQKQVQE | EISRMSSKAM | LKVQEDIKAL | KQLLSLAANG | ||||
| IQRNTLNIDK | LKIETAQELK | NAEIALRTQK | TPPGLQHEYA | APADYFRILV | ||||
| QQFEVQLQQY | RQQIEELENH | LATQANNSHI | TPQDLSMAMQ | KIYQTFVALA | ||||
| AQLQSIHENV | KVLKEQYLGY | RKMFLGDAVD | VFETRRAEAK | KWQNTPRVTT | ||||
| GPTPFSTMPN | AAAVAMAATL | TQQQQPATGP | QPSLGVSFGT | PFGSGIGTGL | ||||
| QSSGLGSSNL | GGFGTSSGFG | CSTTGASTFG | FGTTNKPSGS | LSAGFGSSST | ||||
| SGFNFSNPGI | TASAGLTFGV | SNPASAGFGT | GGQLLQLKKP | PAGNKRGKR |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000139496 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000114797 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
- ^ a b "Entrez Gene: NUPL1 nucleoporin like 1".
- ^ "UniProt, Q9BVL2". Pristupljeno 4. 8. 2021.
Dopunska literatura
- Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Vanjski linkovi
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