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NUDCD3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1WGV
Identifikatori
Aliasi	NUDCD3
Vanjski ID-jevi	OMIM: 610296 MGI: 2144158 HomoloGene: 9097 GeneCards: NUDCD3
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	44,490,658 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	6,150,415 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • unfolded protein binding;
Ćelijska komponenta	• citoplazma; • cytoplasmic dynein complex;
Biološki proces	• Savijanje proteina; • cilium assembly; • protein localization to pericentriolar material; • GO:0007571 developmental process;
	Izvori:Amigo / QuickGO
Ortolozi
	23386
	209586
	ENSG00000015676
	ENSMUSG00000053838
	Q8IVD9
	Q8R1N4
	NM_015332
	NM_173748; NM_001363446
	NP_056147
	NP_776109; NP_001350375
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 3 sa NudC-domenom je protein koji je kod ljudi kodiran genom NUDCD3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 361 aminokiselina, а molekulska težina Da. 40.822^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
METGAAELYD	QALLGILQHV	GNVQDFLRVL	FGFLYRKTDF	YRLLRHPSDR
MGFPPGAAQA	LVLQVFKTFD	HMARQDDEKR	RQELEEKIRR	KEEEEAKTVS
AAAAEKEPVP	VPVQEIEIDS	TTELDGHQEV	EKVQPPGPVK	EMAHGSQEAE
APGAVAGAAE	VPREPPILPR	IQEQFQKNPD	SYNGAVRENY	TWSQDYTDLE
VRVPVPKHVV	KGKQVSVALS	SSSIRVAMLE	ENGERVLMEG	KLTHKINTES
SLWSLEPGKC	VLVNLSKVGE	YWWNAILEGE	EPIDIDKINK	ERSMATVDEE
EQAVLDRLTF	DYHQKLQGKP	QSHELKVHEM	LKKGWDAEGS	PFRGQRFDPA
MFNISPGAVQ	F

Funkcija

Proizvod ovog gena funkcionira za održavanje stabilnosti dineinskog srednjeg lanca. Njegovo osiromašivanje rezultira agregacijom i razgradnjom međuproizvoda dineina, pogrešnom lokalizacijom kompleksa dineina iz kinetohora, mikrotubulskog vretena i polova vretena i gubitak gama-tubulina sa vretenskih polova. Protein se lokalizira u Golgijevom aparatu tokom interfaze, a razine mu se povećavaju nakon translscije G1/S.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000015676 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053838 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NUDCD3 NudC domain containing 3".
^ "UniProt, Q8IVD9" (jezik: engleski). Pristupljeno 27. 9. 2021.

Dopunska literatura

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9039–44. Bibcode:2006PNAS..103.9039Z. doi:10.1073/pnas.0602916103. PMC 1482562. PMID 16754861.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000015676 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053838 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NUDCD3 NudC domain containing 3".

[UniProt-6] "UniProt, Q8IVD9" (jezik: engleski). Pristupljeno 27. 9. 2021.

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NUDCD3

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

Vanjski linkovi

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