DOKUMEN123.COM

NPW
Identifikatori
Aliasi	NPW
Vanjski ID-jevi	OMIM: 607997 MGI: 2685781 HomoloGene: 17727 GeneCards: NPW
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	2,020,755 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	24,877,431 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • G protein-coupled receptor binding;
Ćelijska komponenta	• extracellular region;
Biološki proces	• neuropeptide signaling pathway; • ponašanje pri hranjenju; • G protein-coupled receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	283869
	381073
	ENSG00000183971
	ENSMUSG00000071230
	Q8N729
	Q3V2F0
	NM_001099456
	NM_001099664
	NP_001092926
	NP_001093134
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NPW jegen koji ko ljudi kodoira protein zvani neuropeptid W.^[5]^[6]^[7]

Neuropeptid W (NPW) je endogeni peptidni ligand za GPR8 (MIM 600731), receptor vezan za G-protein (prema OMIM^[7])

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 165 aminokiselina, a molekulska težina 18.048 Da.^[8]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin

S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAWRPGERGA	PASRPRLALL	LLLLLLPLPS	GAWYKHVASP	RYHTVGRAAG
LLMGLRRSPY	LWRRALRAAA	GPLARDTLSP	EPAAREAPLL	LPSWVQELWE
TRRRSSQAGI	PVRAPRSPRA	PEPALEPESL	DFSGAGQRLR	RDVSRPAVDP
AANRLGLPCL	APGPF

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183971 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071230 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7". J Biol Chem. 277 (37): 34010–6. doi:10.1074/jbc.M205883200. PMID 12118011.
^ Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J Biol Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
^ ^a ^b "Entrez Gene: NPW neuropeptide W".
^ "UniProt, Q8N729". Pristupljeno 8. 7. 2021.

Dopunska literatura

Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
Mondal MS, Yamaguchi H, Date Y, et al. (2003). "A role for neuropeptide W in the regulation of feeding behavior". Endocrinology. 144 (11): 4729–33. doi:10.1210/en.2003-0536. PMID 12959997.
Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects". Int. J. Mol. Med. 16 (6): 1021–8. doi:10.3892/ijmm.16.6.1021. PMID 16273281.
Mondal MS, Yamaguchi H, Date Y, et al. (2006). "Neuropeptide W is present in antral G cells of rat, mouse, and human stomach". J. Endocrinol. 188 (1): 49–57. doi:10.1677/joe.1.06195. PMID 16394174.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183971 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071230 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12118011-5] Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7". J Biol Chem. 277 (37): 34010–6. doi:10.1074/jbc.M205883200. PMID 12118011.

[pmid12401809-6] Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J Biol Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.

[entrez-7] "Entrez Gene: NPW neuropeptide W".

[UniProt-8] "UniProt, Q8N729". Pristupljeno 8. 7. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

NPW

Aminokiselinska sekvenca

Reference

Dopunska literatura

Content Disclaimer