MTERF
Mitohondrijskoterminacjski faktor transkripcije 1, znan i kao aMTERF1, jest protein koji je kod ljudi kodiran genom MTERF.[5][6][7][8]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 399 aminokiselina, а molekulska težina 45.778 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MQSLSLGQTS | ISKGLNYLTI | MAPGNLWHMR | NNFLFGSRCW | MTRFSAENIF | ||||
| KSVSFRLFGV | KCHNTDSEPL | KNEDLLKNLL | TMGVDIDMAR | KRQPGVFHRM | ||||
| ITNEQDLKMF | LLSKGASKEV | IASIISRYPR | AITRTPENLS | KRWDLWRKIV | ||||
| TSDLEIVNIL | ERSPESFFRS | NNNLNLENNI | KFLYSVGLTR | KCLCRLLTNA | ||||
| PRTFSNSLDL | NKQMVEFLQA | AGLSLGHNDP | ADFVRKIIFK | NPFILIQSTK | ||||
| RVKANIEFLR | STFNLNSEEL | LVLICGPGAE | ILDLSNDYAR | RSYANIKEKL | ||||
| FSLGCTEEEV | QKFVLSYPDV | IFLAEKKFND | KIDCLMEENI | SISQIIENPR | ||||
| VLDSSISTLK | SRIKELVNAG | CNLSTLNITL | LSWSKKRYEA | KLKKLSRFA |
Funkcija
Ovaj gen kodira transkripciju terminacijskog faktora u mitohondrijama. Protein učestvuje u slabljenju transkripcije iz mitohondrijskog genoma; ovo slabljenje omogućava veće nivoe ekspresije 16S ribosomske RNK u odnosu na nizvodni gen za tRNK. Proizvod ovog gena ima tri motiva leucinskog zatvarača koji su u pregradama povezani s dva osnovna domena koji su oba potrebna za vezivanje DNK. Postoje dokazi da za ovaj protein zatvarači sudjeluju u intramolekulnim interakcijama koje uspostavljaju trodimenzijsku strukturu potrebnu za vezanje DNK.[5]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127989 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053178 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: MTERF mitochondrial transcription termination factor".
- ^ Daga A, Micol V, Hess D, Aebersold R, Attardi G (april 1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. doi:10.1016/S0021-9258(18)53070-2. PMID 7681833. Arhivirano s originala, 17. 4. 2020. Pristupljeno 27. 9. 2021.
- ^ Asin-Cayuela J, Helm M, Attardi G (april 2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi:10.1074/jbc.M312537200. PMID 14744862.
- ^ Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (juli 2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi:10.1074/jbc.M501145200. PMID 15899902.
- ^ "UniProt, Q99551" (jezik: engleski). Pristupljeno 27. 9. 2021.
Dopunska literatura
- Daga A, Micol V, Hess D, et al. (1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. doi:10.1016/S0021-9258(18)53070-2. PMID 7681833.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Fernandez-Silva P, Martinez-Azorin F, Micol V, Attardi G (1997). "The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions". EMBO J. 16 (5): 1066–79. doi:10.1093/emboj/16.5.1066. PMC 1169706. PMID 9118945.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Asin-Cayuela J, Helm M, Attardi G (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi:10.1074/jbc.M312537200. PMID 14744862.
- Prieto-Martín A, Montoya J, Martínez-Azorín F (2004). "Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not for binding to DNA". Nucleic Acids Res. 32 (7): 2059–68. doi:10.1093/nar/gkh528. PMC 407814. PMID 15087485.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi:10.1074/jbc.M501145200. PMID 15899902.
- Hyvärinen AK, Pohjoismäki JL, Reyes A, et al. (2007). "The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA". Nucleic Acids Res. 35 (19): 6458–74. doi:10.1093/nar/gkm676. PMC 2095818. PMID 17884915.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.