MIA2
Melanomski inhibitorno aktivni protein 2 je protein koji je kod ljudi kodiran genom MIA2.[3][4]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.412 aminokiselina, a molekulska težina 159.836 Da [5].
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAKFGVHRIL | LLAISLTKCL | ESTKLLADLK | KCGDLECEAL | INRVSAMRDY | ||||
| RGPDCRYLNF | TKGEEISVYV | KLAGEREDLW | AGSKGKEFGY | FPRDAVQIEE | ||||
| VFISEEIQMS | TKESDFLCLL | GVSYTFDNED | SELNGDYGEN | IYPYEEDKDE | ||||
| KSSIYESDFQ | IEPGFYATYE | STLFEDQVPA | LEAPEDIGST | SESKDWEEVV | ||||
| VESMEQDRIP | EVHVPPSSAV | SGVKEWFGLG | GEQAEEKAFE | SVIEPVQESS | ||||
| FRSRKIAVED | ENDLEELNNG | EPQTEHQQES | ESEIDSVPKT | QSELASESEH | ||||
| IPKPQSTGWF | GGGFTSYLGF | GDEDTGLELI | AEESNPPLQD | FPNSISSDKE | ||||
| ATVPCTEILT | EKKDTITNDS | LSLKPSWFDF | GFAILGFAYA | KEDKIMLDDR | ||||
| KNEEDGGADE | HEHPLTSELD | PEKEQEIETI | KIIETEDQID | KKPVSEKTDE | ||||
| SDTIPYLKKF | LYNFDNPWNF | QNIPKETELP | FPKQILDQNN | VIENEETGEF | ||||
| SIDNYPTDNT | KVMIFKSSYS | LSDMVSNIEL | PTRIHEEVYF | EPSSSKDSDE | ||||
| NSKPSVDTEG | PALVEIDRSV | ENTLLNSQMV | STDNSLSSQN | YISQKEDASE | ||||
| FQILKYLFQI | DVYDFMNSAF | SPIVILTERV | VAALPEGMRP | DSNLYGFPWE | ||||
| LVICAAVVGF | FAVLFFLWRS | FRSVRSRLYV | GREKKLALML | SGLIEEKSKL | ||||
| LEKFSLVQKE | YEGYEVESSL | KDASFEKEAT | EAQSLEATCE | KLNRSNSELE | ||||
| DEILCLEKEL | KEEKSKHSEQ | DELMADISKR | IQSLEDESKS | LKSQVAEAKM | ||||
| TFKIFQMNEE | RLKIAIKDAL | NENSQLQESQ | KQLLQEAEVW | KEQVSELNKQ | ||||
| KVTFEDSKVH | AEQVLNDKES | HIKTLTERLL | KMKDWAAMLG | EDITDDDNLE | ||||
| LEMNSESENG | AYLDNPPKGA | LKKLIHAAKL | NASLKTLEGE | RNQIYIQLSE | ||||
| VDKTKEELTE | HIKNLQTEQA | SLQSENTHFE | NENQKLQQKL | KVMTELYQEN | ||||
| EMKLHRKLTV | EENYRLEKEE | KLSKVDEKIS | HATEELETYR | KRAKDLEEEL | ||||
| ERTIHSYQGQ | IISHEKKAHD | NWLAARNAER | NLNDLRKENA | HNRQKLTETE | ||||
| LKFELLEKDP | YALDVPNTAF | GREHSPYGPS | PLGWPSSETR | AFLSPPTLLE | ||||
| GPLRLSPLLP | GGGGRGSRGP | GNPLDHQITN | ERGESSCDRL | TDPHRAPSDT | ||||
| GSLSPPWDQD | RRMMFPPPGQ | SYPDSALPPQ | RQDRFCSNSG | RLSGPAELRS | ||||
| FNMPSLDKMD | GSMPSEMESS | RNDTKDDLGN | LNVPDSSLPA | ENEATGPGFV | ||||
| PPPLAPIRGP | LFPVDARGPF | LRRGPPFPPP | PPGAMFGASR | DYFPPGDFPG | ||||
| PPPAPFAMRN | VYPPRGFPPY | LPPRPGFFPP | PPHSEGRSEF | PSGLIPPSNE | ||||
| PATEHPEPQQ | ET |
Reference
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bosserhoff AK, Moser M, Scholmerich J, Buettner R, Hellerbrand C (Apr 2003). "Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes". J Biol Chem. 278 (17): 15225–31. doi:10.1074/jbc.M212639200. PMID 12586826.
- ^ "Entrez Gene: MIA2 melanoma inhibitory activity 2".
- ^ "UniProt, Q96PC5". Pristupljeno 27. 7. 2021.
Dopunska literatura
- Hellerbrand C, Amann T, Schlegel J, et al. (2008). "The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma" (PDF). Gut. 57 (2): 243–51. doi:10.1136/gut.2007.129544. PMID 17881540.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
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