METRN

METRN
Identifikatori
AliasiMETRN
Vanjski ID-jeviOMIM: 610998 MGI: 1917333 HomoloGene: 11432 GeneCards: METRN
Lokacija gena (čovjek)
Hromosom 16 (čovjek)
Hrom.Hromosom 16 (čovjek)[1]
Hromosom 16 (čovjek)
Genomska lokacija za METRN
Genomska lokacija za METRN
Bend16p13.3Početak715,118 bp[1]
Kraj719,655 bp[1]
Lokacija gena (miš)
Hromosom 17 (miš)
Hrom.Hromosom 17 (miš)[2]
Hromosom 17 (miš)
Genomska lokacija za METRN
Genomska lokacija za METRN
Bend17|17 A3.3Početak26,012,195 bp[2]
Kraj26,016,110 bp[2]
Ontologija gena
Molekularna funkcija• hormone activity
Ćelijska komponenta• extracellular region
• Vanćelijsko
Biološki proces• multicellular organism development
• Ćelijska diferencijacija
• glial cell differentiation
• positive regulation of axonogenesis
• nervous system development
• GO:0072468 Transdukcija signala
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

79006

70083

Ensembl

ENSG00000103260

ENSMUSG00000002274

UniProt

Q9UJH8

Q8C1Q4

RefSeq (mRNK)

NM_024042

NM_133719

RefSeq (bjelančevina)

NP_076947

NP_598480

Lokacija (UCSC)Chr 16: 0.72 – 0.72 MbChr 17: 26.01 – 26.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Meteorin, glijski regulator ćelijske diferencijacije je protein koji je kod ljudi kodiran genom METRN.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 293 aminokiseline, a molekulska težina 31.207 Da.[6].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

1020304050
MGFPAAALLCALCCGLLAPAARAGYSEERCSWRGSGLTQEPGSVGQLALA
CAEGAVEWLYPAGALRLTLGGPDPRARPGIACLRPVRPFAGAQVFAERAG
GALELLLAEGPGPAGGRCVRWGPRERRALFLQATPHQDISRRVAAFRFEL
REDGRPELPPQAHGLGVDGACRPCSDAELLLAACTSDFVIHGIIHGVTHD
VELQESVITVVAARVLRQTPPLFQAGRSGDQGLTSIRTPLRCGVHPGPGT
FLFMGWSRFGEARLGCAPRFQEFRRAYEAARAAHLHPCEVALH

Funkcija

Meteorin regulira diferencijaciju glijskih ćelija i pospješuje stvaranje aksonskih mreža tokom neurogeneze (Nishino et al., 2004 [PubMed 15085178]).

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103260 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002274 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Meteorin, glial cell differentiation regulator". Pristupljeno 25. 2. 2016.
  6. ^ "UniProt, Q9UJH8". Pristupljeno 7. 7. 2021.

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