MEAF6

MEAF6
Identifikatori
AliasiMEAF6
Vanjski ID-jeviOMIM: 611001 MGI: 1917338 HomoloGene: 11240 GeneCards: MEAF6
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za MEAF6
Genomska lokacija za MEAF6
Bend1p34.3Početak37,489,993 bp[1]
Kraj37,514,766 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za MEAF6
Genomska lokacija za MEAF6
Bend4|4 D2.2Početak124,978,927 bp[2]
Kraj125,007,031 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
histone acetyltransferase activity (H3-K23 specific)
Ćelijska komponenta NuA4 histone acetyltransferase complex
MOZ/MORF histone acetyltransferase complex
histone acetyltransferase complex
jedro
Jedarce
hromosom
kinetohor
Primarno suženje
nukleoplazma
NuA3a histone acetyltransferase complex
NuA3b histone acetyltransferase complex
Biološki proces histone H4-K12 acetylation
GO:0009373 regulation of transcription, DNA-templated
histone H4-K5 acetylation
histone acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
histone H3-K14 acetylation
histone H2A acetylation
transcription, DNA-templated
regulation of signal transduction by p53 class mediator
GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
histone H3-K23 acetylation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001270875
NM_001270876
NM_022756

NM_001290701
NM_027310
NM_001374123

RefSeq (bjelančevina)

NP_001257804
NP_001257805
NP_073593

NP_001277630
NP_081586
NP_001361052

Lokacija (UCSC)Chr 1: 37.49 – 37.51 MbChr 4: 124.98 – 125.01 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein MEAF6 vezan za modifikaciju hromatina jest protein koji je kod ljudi kodiran genom MEAF6 sa hromosoma 1.[5][6][7][8][9][10]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 191 aminokiselina, a molekulska težina 21.635 Da.[11]

1020304050
MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLED
TQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAV
SALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGV
KPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
  8. ^ Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
  9. ^ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
  10. ^ "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".
  11. ^ "UniProt, Q9HAF1" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

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