MDFIC

MDFIC
Identifikatori
AliasiMDFIC
Vanjski ID-jeviOMIM: 614511 MGI: 104611 HomoloGene: 18404 GeneCards: MDFIC
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za MDFIC
Genomska lokacija za MDFIC
Bend7q31.1-q31.2Početak114,922,094 bp[1]
Kraj115,019,917 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za MDFIC
Genomska lokacija za MDFIC
Bend6|6 A1Početak15,720,660 bp[2]
Kraj15,802,168 bp[2]
Ontologija gena
Molekularna funkcija• transcription factor binding
• Tat protein binding
• GO:0001948, GO:0016582 vezivanje za proteine
• cyclin binding
Ćelijska komponenta• Jedarce
• jedro
• citoplazma
• Golđijev aparat
• nukleoplazma
Biološki proces• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• positive regulation of viral transcription
• regulation of Wnt signaling pathway
• GO:0022415 viral process
• GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• negative regulation of protein import into nucleus
• GO:0045996 negative regulation of transcription, DNA-templated
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

29969

16543

Ensembl

ENSG00000135272

ENSMUSG00000041390

UniProt

Q9P1T7

Q8BX65

RefSeq (mRNK)

NM_199072
NM_001166345
NM_001166346

NM_175088

RefSeq (bjelančevina)

NP_001159817
NP_001159818
NP_951038

NP_780297

Lokacija (UCSC)Chr 7: 114.92 – 115.02 MbChr 6: 15.72 – 15.8 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein porodice inhibitora MyoD sa domenom je protein koji je kod ljudi kodiran genom MDFIC.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je aminokiselina, а molekulska težina 25.788 Da.[6]

1020304050
MSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTEKDITQATNSH
FTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNGH
TGLSNGNGIHHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSK
VNAVFSQKTGSSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEAC
CCCCGDEMGDDCNCPCDMDCGIMDACCESSDCLEICMECCGICFPS

Funkcija

Ovaj genski proizvod je član porodice proteina koje karakterizira specifična cistein-bogati C-terminalni domen, koji je uključen u regulaciju transkripcije u ekspresiji virusniog genom. Alternativno započinjanje prevođenja iz uzvodnog ne-AUG (GUG), i unutar okvira, nizvodnog AUG kodona, rezultira proizvodnjom dvije izoforme, p40 i p32, koje imaju različitu subćelijsku lokalizaciju; p32 se uglavnom nalazi u citoplazmi, dok je p40 usmjeren na jedarce. Obje izoforme imaju transkripcijsku regulatornu aktivnost koja se može pripisati C-terminalnom domenu bogatom cisteinom. Alternativne prerada rezultira u više varijanti transkripta.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135272 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041390 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MyoD family inhibitor domain containing". Pristupljeno 9. 2. 2016.
  6. ^ "UniProt, Q9P1T7". Pristupljeno 26. 9. 2021.

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