LPCAT1

LPCAT1
Identifikatori
AliasiLPCAT1
Vanjski ID-jeviOMIM: 610472 MGI: 2384812 HomoloGene: 9871 GeneCards: LPCAT1
EC broj2.3.1.23+ 2.3.1.25+ 2.3.1.51 2.3.1.67, 2.3.1.23, 2.3.1.25, 2.3.1.51
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za LPCAT1
Genomska lokacija za LPCAT1
Bend5p15.33Početak1,456,480 bp[1]
Kraj1,523,962 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za LPCAT1
Genomska lokacija za LPCAT1
Bend13|13 C1Početak73,615,316 bp[2]
Kraj73,664,541 bp[2]
Ontologija gena
Molekularna funkcija• 1-alkylglycerophosphocholine O-acyltransferase activity
• vezivanje iona metala
• calcium ion binding
• aktivnost sa transferazom
• acyltransferase activity
• 1-alkylglycerophosphocholine O-acetyltransferase activity
• 1-alkenylglycerophosphocholine O-acyltransferase activity
• 1-acylglycerophosphocholine O-acyltransferase activity
• 1-acylglycerol-3-phosphate O-acyltransferase activity
• 2-acylglycerol-3-phosphate O-acyltransferase activity
Ćelijska komponenta• integral component of membrane
• Golđijev aparat
• Golđijeva membrana
• membrana
• Lipidna kapljica
• endoplasmic reticulum membrane
• Endoplazmatski retikulum
• ćelijska membrana
• azurophil granule membrane
Biološki proces• phospholipid biosynthetic process
• retina development in camera-type eye
• lipid metabolism
• phosphatidylglycerol acyl-chain remodeling
• GO:1903364 positive regulation of protein catabolic process
• phosphatidic acid biosynthetic process
• metabolizam
• surfactant homeostasis
• negative regulation of phosphatidylcholine biosynthetic process
• phosphatidylcholine acyl-chain remodeling
• phospholipid metabolic process
• phosphatidylcholine biosynthetic process
• neutrophil degranulation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

79888

210992

Ensembl

ENSG00000275079
ENSG00000153395

ENSMUSG00000021608

UniProt

Q8NF37

Q3TFD2

RefSeq (mRNK)

NM_024830

NM_145376
NM_001368681
NM_001368682

RefSeq (bjelančevina)

NP_079106

NP_663351
NP_001355610
NP_001355611

Lokacija (UCSC)Chr 5: 1.46 – 1.52 MbChr 13: 73.62 – 73.66 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Lizofosfatidilholin-aciltransferaza 1 jest protein/enzim koji je kod ljudi kodiran genom LPCAT1 sa hromosoma 5.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je aminokiselina, а molekulska težina 59.151 Da.[6]

1020304050
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMT
LTLFPVRLLVAAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLK
AIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSS
IVMKAESRDIPIWGTLIQYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKW
PQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPNKLDTITWTWQ
GPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE
ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEK
DLDRYSERARMKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVD
LRECVVALSVVCRPARTLDTIQLAFKMYGAQEDGSVGEGDLSCILKTALG
VAELTVTDLFRAIDQEEKGKITFADFHRFAEMYPAFAEEYLYPDQTHFES
CAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD

Funkcija

Lizofosfatidilholin (LPC) aciltransferaza (LPCAT; EC 2.3.1.23) katalizira pretvorbu LPC u fosfatidilholin (PC) na putu remodeliranja biosinteze PC-a.[7]

Reference

  1. ^ a b c ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021608 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
  6. ^ "UniProt, Q8NF37" (jezik: engleski). Pristupljeno 16. 10. 2021.
  7. ^ Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

Vanjski linkovi

Šablon:PAF signalizacija

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.