LMLN

LMLN
Identifikatori
AliasiLMLN
Vanjski ID-jeviOMIM: 609380 MGI: 2444736 HomoloGene: 13198 GeneCards: LMLN
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za LMLN
Genomska lokacija za LMLN
Bend3q29Početak197,960,200 bp[1]
Kraj198,043,720 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za LMLN
Genomska lokacija za LMLN
Bend16|16 B3Početak32,882,891 bp[2]
Kraj32,948,065 bp[2]
Ontologija gena
Molekularna funkcija• GO:0070122 peptidase activity
• metalloendopeptidase activity
• hydrolase activity
• metallopeptidase activity
• vezivanje iona metala
Ćelijska komponenta• Lipidna kapljica
• membrana
• focal adhesion
• citoplazma
• citosol
Biološki proces• ćelijski ciklus
• Ćelijska adhezija
• Proteoliza
• Ćelijska dioba
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

89782

239833

Ensembl

ENSG00000185621

ENSMUSG00000022802

UniProt

Q96KR4

Q8BMN4

RefSeq (mRNK)

NM_001136049
NM_033029

NM_172823

RefSeq (bjelančevina)

NP_001129521
NP_149018

NP_766411

Lokacija (UCSC)Chr 3: 197.96 – 198.04 MbChr 16: 32.88 – 32.95 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Leishmanolizinoliki protein porodice metalopeptidaza M8 jest protein koji je kod ljudi kodiran genom LMLN sa hromosoma 3.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 655 aminokiselina, а molekulska težina 73.568 Da.[6]

1020304050
MVTTLGPKMAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRAS
ATSTPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVY
DKSVEELLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQ
YLRKENDPHRYCTGECAAHTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGV
PDQEGISDADFVLYVGALATERCSHENIISYAAYCQQEANMDRPIAGYAN
LCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGLFAFYHDKDGNPLTSRF
ADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYLLVTPRVVE
EARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLS
RITLALMEDTGRQMLSPYCDTLRSNPLQLTCRQDQRAVAVCNLQKFPKPL
PQEYQYFDELSGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSD
CRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGC
YQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWD
FCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFL
LCIWH

Funkcija

Ovaj gen kodira enzim]] [[cink-metalopeptidaza. Kodirani protein može imati ulogu u invaziji i migraciji ćelija. Studije sličnog proteina u Drosophila ukazuju na potencijalnu ulogu u progresiji mitoze. Opisane su alternativno prerađenee varijante transkripta (prema RefSeq, feb 2009).

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185621 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022802 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Leishmanolysin-like (metallopeptidase M8 family)".
  6. ^ "UniProt, Q96KR4" (jezik: engleski). Pristupljeno 8. 11. 2021.

Dopunska literatura

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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