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LGI2
Identifikatori
Aliasi	LGI2
Vanjski ID-jevi	OMIM: 608301 MGI: 2180196 HomoloGene: 10048 GeneCards: LGI2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	25,030,946 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	52,723,804 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ortolozi
	55203
	246316
	ENSG00000153012
	ENSMUSG00000039252
	Q8N0V4
	Q8K4Z0
	NM_018176
	NM_144945; NM_001310604
	NP_060646
	NP_001297533; NP_659194
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 2 porodice leucinski bogatih ponavljanja LGI jest protein koji je kod ljudi kodiran genom LGI2 sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 545 aminokiselina, а molekulska težina 62.298 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALRRGGCGA	LGLLLLLLGA	ACLIPRSAQV	RRLARCPATC	SCTKESIICV
GSSWVPRIVP	GDISSLSLVN	GTFSEIKDRM	FSHLPSLQLL	LLNSNSFTII
RDDAFAGLFH	LEYLFIEGNK	IETISRNAFR	GLRDLTHLSL	ANNHIKALPR
DVFSDLDSLI	ELDLRGNKFE	CDCKAKWLYL	WLKMTNSTVS	DVLCIGPPEY
QEKKLNDVTS	FDYECTTTDF	VVHQTLPYQS	VSVDTFNSKN	DVYVAIAQPS
MENCMVLEWD	HIEMNFRSYD	NITGQSIVGC	KAILIDDQVF	VVVAQLFGGS
HIYKYDESWT	KFVKFQDIEV	SRISKPNDIE	LFQIDDETFF	VIADSSKAGL
STVYKWNSKG	FYSYQSLHEW	FRDTDAEFVD	IDGKSHLILS	SRSQVPIILQ
WNKSSKKFVP	HGDIPNMEDV	LAVKSFRMQN	TLYLSLTRFI	GDSRVMRWNS
KQFVEIQALP	SRGAMTLQPF	SFKDNHYLAL	GSDYTFSQIY	QWDKEKQLFK
KFKEIYVQAP	RSFTAVSTDR	RDFFFASSFK	GKTKIFEHII	VDLSL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153012 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039252 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK (maj 2002). "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins". FEBS Lett. 519 (1–3): 71–6. doi:10.1016/S0014-5793(02)02713-8. PMID 12023020. S2CID 41639083.
^ Gu W, Gibert Y, Wirth T, Elischer A, Bloch W, Meyer A, Steinlein OK, Begemann G (Oct 2005). "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders". Mol Biol Evol. 22 (11): 2209–16. doi:10.1093/molbev/msi214. PMID 16014869.
^ "Entrez Gene: LGI2 leucine-rich repeat LGI family, member 2".
^ "UniProt, Q8N0V4" (jezik: engleski). Pristupljeno 29. 10. 2021.

Dopunska literatura

Staub E, Pérez-Tur J, Siebert R, et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. doi:10.1016/S0968-0004(02)02163-1. PMID 12217514.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
Scheel H, Tomiuk S, Hofmann K (2003). "A common protein interaction domain links two recently identified epilepsy genes". Hum. Mol. Genet. 11 (15): 1757–62. doi:10.1093/hmg/11.15.1757. PMID 12095917.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153012 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039252 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12023020-5] Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK (maj 2002). "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins". FEBS Lett. 519 (1–3): 71–6. doi:10.1016/S0014-5793(02)02713-8. PMID 12023020. S2CID 41639083.

[pmid16014869-6] Gu W, Gibert Y, Wirth T, Elischer A, Bloch W, Meyer A, Steinlein OK, Begemann G (Oct 2005). "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders". Mol Biol Evol. 22 (11): 2209–16. doi:10.1093/molbev/msi214. PMID 16014869.

[entrez-7] "Entrez Gene: LGI2 leucine-rich repeat LGI family, member 2".

[UniProt-8] "UniProt, Q8N0V4" (jezik: engleski). Pristupljeno 29. 10. 2021.

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LGI2

Aminokiselinska sekvenca

Reference

Dopunska literatura

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