LANCL1

LANCL1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3E6U, 3E73

Identifikatori
AliasiLANCL1
Vanjski ID-jeviOMIM: 604155 MGI: 1336997 HomoloGene: 4417 GeneCards: LANCL1
EC broj2.5.1.18
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za LANCL1
Genomska lokacija za LANCL1
Bend2q34Početak210,431,249 bp[1]
Kraj210,477,652 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za LANCL1
Genomska lokacija za LANCL1
Bend1|1 C3Početak67,039,676 bp[2]
Kraj67,078,031 bp[2]
Ontologija gena
Molekularna funkcija• SH3 domain binding
• low-density lipoprotein particle receptor binding
• vezivanje iona cinka
• GO:0001948, GO:0016582 vezivanje za proteine
• G protein-coupled receptor activity
• vezivanje iona metala
• glutathione binding
• catalytic activity
• glutathione transferase activity
• aktivnost sa transferazom
Ćelijska komponenta• citoplazma
• integral component of plasma membrane
• membrana
• ćelijska membrana
Biološki proces• G protein-coupled receptor signaling pathway
• regulation of neuron apoptotic process
• regulation of oxidative stress-induced neuron death
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

10314

14768

Ensembl

ENSG00000115365

ENSMUSG00000026000

UniProt

O43813

O89112

RefSeq (mRNK)

NM_001136574
NM_001136575
NM_006055

NM_001190984
NM_001190985
NM_021295

RefSeq (bjelančevina)

NP_001130046
NP_001130047
NP_006046

NP_001177913
NP_001177914
NP_067270

Lokacija (UCSC)Chr 2: 210.43 – 210.48 MbChr 1: 67.04 – 67.08 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

LanC-liki protein 1 jest protein koji je kod ljudi kodiran genom LANCL1 sa hromosoma 2.[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 399 aminokiselina, a molekulska težina 45.283 Da.[6]

1020304050
MAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMERG
LKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLT
KRSITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNE
MLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFT
AKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDY
VCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEKYLC
DAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACK
FAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL

Funkcija

Ovaj gen kodira slabo povezan periferni membranski protein povezan s proteinima porodice LanC povezanim s bakterijskom membranom uključenim u biosintezu antimikrobnih peptida. Ovaj protein može imati ulogu peptidne komponente koja modificira enzim u eukariotskim ćelijama. Ranije se smatrao članom natporodice G-proteinspregnutih receptora, ali je sada u porodici LanC. Identificirano je više alternativno prerađenih varijanti, koje kodiraju isti protein.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115365 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026000 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LanC like 1". Pristupljeno 20. 4. 2016.
  6. ^ "UniProt, O43813" (jezik: engleski). Pristupljeno 17. 11. 2021.

Dopunska literatura

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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