IFT122

IFT122
Identifikatori
AliasiIFT122
Vanjski ID-jeviOMIM: 606045 MGI: 1932386 HomoloGene: 12819 GeneCards: IFT122
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za IFT122
Genomska lokacija za IFT122
Bend3q21.3-q22.1Početak129,429,607 bp[1]
Kraj129,520,510 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za IFT122
Genomska lokacija za IFT122
Bend6|6 E3Početak115,830,431 bp[2]
Kraj115,903,660 bp[2]
Ontologija gena
Molekularna funkcija• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta• citoplazma
• ciliary basal body
• projekcija ćelije
• membrana
• intraciliary transport particle A
• photoreceptor connecting cilium
• ciliary base
• ciliary tip
• citoskelet
• nukleoplazma
• citosol
• Treplja
Biološki proces• intraciliary anterograde transport
• negative regulation of smoothened signaling pathway
• embryonic body morphogenesis
• embryonic heart tube left/right pattern formation
• embryonic digit morphogenesis
• ciliary receptor clustering involved in smoothened signaling pathway
• negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
• signal transduction downstream of smoothened
• embryonic heart tube development
• limb development
• multicellular organism development
• neural tube closure
• smoothened signaling pathway involved in dorsal/ventral neural tube patterning
• cell projection organization
• protein localization to cilium
• negative regulation of epithelial cell proliferation
• intraciliary retrograde transport
• establishment of protein localization to organelle
• dorsal/ventral pattern formation
• embryonic forelimb morphogenesis
• camera-type eye morphogenesis
• intraciliary transport involved in cilium assembly
• non-motile cilium assembly
• cilium assembly
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

55764

81896

Ensembl

ENSG00000163913

ENSMUSG00000030323

UniProt

Q9HBG6

Q6NWV3

RefSeq (mRNK)
NM_001280541
NM_001280545
NM_001280546
NM_018262
NM_052985

NM_052989
NM_052990

NM_001167763
NM_031177

RefSeq (bjelančevina)
NP_001267470
NP_001267474
NP_001267475
NP_060732
NP_443711

NP_443715
NP_443716

NP_001161235
NP_112454

Lokacija (UCSC)Chr 3: 129.43 – 129.52 MbChr 6: 115.83 – 115.9 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Međuflagelski transportni protein 122 jest protein koji je kod ljudi kodiran genom IFT122 sa hromosoma 3.[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.241 aminokiselina, a molekulska težina 141.825 Da.[5]

1020304050
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLK
GHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVS
YNPITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALG
MFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNRENE
DAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEER
NDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS
DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQL
IFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNR
LAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNLLVVCANHIILCQ
EKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKI
FVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELLF
QEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS
KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELA
MEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVF
SYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKML
ITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKL
DKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEA
FALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ
LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAE
LYHGYHAIHRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILF
TLAKQSKALGAYRLARHAYDKLRGLYIPARFQKSIELGTLTIRAKPFHDS
EELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEE
GITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDPF
TAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP
DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP

Funkcija

Protein kodiran ovim genom ima za funkciju u razvoju organizma. Učešće u takvim biološkim procesima, kao što je biogeneza i degradacija trepavica, omogučava alternativna prerada, sa izoformama.

Lokaliziran u citoplazmi, citoskeletu, ćelijskim procesima, trepavicama.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163913 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030323 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "HUGO Gene Nomenclature Commitee, HGNC:13556" (jezik: engleski). Arhivirano s originala, 13. 10. 2017. Pristupljeno 18. 9. 2017.
  6. ^ "UniProt, Q9HBG6" (jezik: engleski). Pristupljeno 18. 9. 2017.

Dopunska literatura

  • Gross C., De Baere E., Lo A., Chang W., Messiaen L. (2001). "Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis". DNA Cell Biol. 20: 41–52.CS1 održavanje: upotreba parametra authors (link) PubMed doi:10.1089/10445490150504684
  • NIH (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14: 2121–2127. PubMed doi:10.1101/gr.2596504

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