HES2

HES2
Identifikatori
AliasiHES2
Vanjski ID-jeviOMIM: 609970 MGI: 1098624 HomoloGene: 22455 GeneCards: HES2
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za HES2
Genomska lokacija za HES2
Bend1p36.31Početak6,412,418 bp[1]
Kraj6,424,670 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za HES2
Genomska lokacija za HES2
Bend4 E2|4 82.92 cMPočetak152,243,324 bp[2]
Kraj152,246,926 bp[2]
Ontologija gena
Molekularna funkcija• vezivanje sa DNK
• double-stranded DNA binding
• transcription factor binding
• protein dimerization activity
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001106 transcription corepressor activity
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
Ćelijska komponenta• jedro
Biološki proces• GO:0045996 negative regulation of transcription, DNA-templated
• GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• GO:1901227 negative regulation of transcription by RNA polymerase II
• somitogenesis
• Notch signaling pathway
• Ćelijska diferencijacija
• regulation of neurogenesis
• anterior/posterior pattern specification
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

54626

15206

Ensembl

ENSG00000069812

ENSMUSG00000028940

UniProt

Q9Y543

O54792

RefSeq (mRNK)

NM_019089

NM_001301805
NM_008236

RefSeq (bjelančevina)

NP_061962

NP_001288734
NP_032262

Lokacija (UCSC)Chr 1: 6.41 – 6.42 MbChr 4: 152.24 – 152.25 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Transkripcijski faktor 2 Hes porodice bHLH jest protein koji je kod ljudi kodiran genom HES2 sa hromosoma 1.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 173 aminokiselina, a molekulska težina. 18.470 Da[6]

1020304050
MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSN
CSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARV
LPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAP
EPASAPVPSPPSPPCGPGLWRPW

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069812 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028940 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Hes family bHLH transcription factor 2".
  6. ^ "UniProt, Q9Y543" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Vanjski linkovi

Šablon:Transkripcijski faktori i unutarćelijski receptori

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