HAO2

HAO2
Identifikatori
AliasiHAO2
Vanjski ID-jeviOMIM: 605176 MGI: 96012 HomoloGene: 97412 GeneCards: HAO2
EC broj1.1.3.15
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za HAO2
Genomska lokacija za HAO2
Bend1p12Početak119,368,779 bp[1]
Kraj119,394,130 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za HAO2
Genomska lokacija za HAO2
Bend3 F2.2|3 42.9 cMPočetak98,781,837 bp[2]
Kraj98,800,555 bp[2]
Ontologija gena
Molekularna funkcija• (S)-2-hydroxy-acid oxidase activity
• oxidoreductase activity
• FMN binding
• signaling receptor binding
• catalytic activity
Ćelijska komponenta• Peroksisom
• peroxisomal matrix
• citosol
Biološki proces• fatty acid oxidation
• fatty acid catabolic process
• protein targeting to peroxisome
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

51179

56185

Ensembl

ENSG00000116882

ENSMUSG00000027870

UniProt

Q9NYQ3

Q9NYQ2

RefSeq (mRNK)

NM_001005783
NM_016527

NM_019545

RefSeq (bjelančevina)

NP_001005783
NP_057611
NP_001364401

NP_062418

Lokacija (UCSC)Chr 1: 119.37 – 119.39 MbChr 3: 98.78 – 98.8 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Hidroksikisela oksidaza 2 jest enzim koji je kod ljudi kodiran genom HAO2 sa hromosoma 1.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 351 aminokiselina, a molekulska težina 38.839 Da.[6]

1020304050
MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPR
YLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAG
ICYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGF
KALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPIS
TSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQ
LDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLG
RPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSR
L

Funkcija

Ovaj gen je jedan od tri srodna gena koji imaju aktivnost 2-hidroksikisele oksidaze. Kodirani protein lokaliziran na peroksisomima ima najveću aktivnost prema supstratu 2-hidroksipalmitatu. Alternativna prerada rezultira višestrukim varijantama transkripta.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116882 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027870 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Hydroxyacid oxidase 2". Pristupljeno 3. 7. 2016.
  6. ^ "UniProt, Q9NYQ3" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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