HACD2

HACD2
Identifikatori
AliasiHACD2
Vanjski ID-jeviOMIM: 615939 MGI: 1918007 HomoloGene: 23409 GeneCards: HACD2
EC broj4.2.1.134
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za HACD2
Genomska lokacija za HACD2
Bend3q21.1Početak123,490,820 bp[1]
Kraj123,585,053 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za HACD2
Genomska lokacija za HACD2
Bend16|16 B3Početak34,842,798 bp[2]
Kraj34,929,547 bp[2]
Ontologija gena
Molekularna funkcija• protein tyrosine phosphatase activity
• vezivanje enzima
• 3-hydroxyacyl-CoA dehydratase activity
• GO:0001948, GO:0016582 vezivanje za proteine
• lyase activity
• 3R-hydroxyacyl-CoA dehydratase activity
• 3-hydroxy-behenoyl-CoA dehydratase activity
• 3-hydroxy-lignoceroyl-CoA dehydratase activity
• 3-hydroxy-arachidoyl-CoA dehydratase activity
• very-long-chain 3-hydroxyacyl-CoA dehydratase activity
Ćelijska komponenta• integral component of membrane
• endoplasmic reticulum membrane
• Endoplazmatski retikulum
• membrana
• integral component of endoplasmic reticulum membrane
Biološki proces• fatty acid elongation
• fatty acid biosynthetic process
• sphingolipid biosynthetic process
• long-chain fatty-acyl-CoA biosynthetic process
• very long-chain fatty acid biosynthetic process
• fatty acid metabolic process
• lipid metabolism
• peptidyl-tyrosine dephosphorylation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

201562

70757

Ensembl

ENSG00000206527

ENSMUSG00000035376

UniProt

Q6Y1H2

Q9D3B1

RefSeq (mRNK)

NM_001329783
NM_001329784
NM_001329786
NM_001329787
NM_198402

NM_023587

RefSeq (bjelančevina)

NP_001316712
NP_001316713
NP_001316715
NP_001316716
NP_940684

NP_076076

Lokacija (UCSC)Chr 3: 123.49 – 123.59 MbChr 16: 34.84 – 34.93 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

3-Hidroksiacil-CoA dehidrataza 2 jest protein/enzim koji je kod ljudi kodiran genom HACD2 sa hromosoma 3.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 254 aminokiseline, а molekulska težina 28.368 Da.[6]

1020304050
MAAVAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMT
AGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGIV
PSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYS
FYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLY
SISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHTEEH
KKFE

Funkcija

Protein kodiran ovim genom može katalizirati treći korak (dehidracija) u konverziji dugolančanih masnih kiselina u vrlo dugolančane masne kiseline. Kodirani protein nalazi se na membrani endoplazmatskog retikuluma.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000206527 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035376 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: 3-hydroxyacyl-CoA dehydratase 2". Pristupljeno 22. 9. 2017.
  6. ^ "UniProt, Q6Y1H2" (jezik: engleski). Pristupljeno 8. 11. 2021.

Dopunska literatura

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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