GMPPB

GMPPB
Identifikatori
AliasiGMPPB
Vanjski ID-jeviOMIM: 615320 MGI: 2660880 HomoloGene: 5578 GeneCards: GMPPB
EC broj2.7.7.13
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[1]
Hromosom 9 (miš)
Genomska lokacija za GMPPB
Genomska lokacija za GMPPB
Bend9|9 F1Početak107,926,441 bp[1]
Kraj107,930,000 bp[1]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
mannose-1-phosphate guanylyltransferase activity
nucleotide binding
nucleotidyltransferase activity
GTP binding
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta citoplazma
Biološki proces Biosinteza
GDP-mannose biosynthetic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_021971
NM_013334

NM_177910
NM_001357682

RefSeq (bjelančevina)

NP_037466
NP_068806

NP_808578
NP_001344611

Lokacija (UCSC)n/aChr 9: 107.93 – 107.93 Mb
PubMed pretraga[2][3]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Manoza-1-fosfat guaniltransferaza beta jest enzim koji je kod ljudi kodiran genom GMPPB sa hromosoma 3.[4]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 360 aminokiselina, а molekulska težina 39.834 Da.[5]

1020304050
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVI
LAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSET
ADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCE
ADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEVFPI
MAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGI
VGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
SWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIG
ESVPEPRIIM

Funkcija

Smatra se da ovaj gen kodira GDP-manoza pirofosforilazu. Ovaj enzim katalizuje reakciju koja pretvara manoza-1-fosfat i GTP u GDP-manozu koja je uključena u proizvodnju N-vezanih oligosaharida. Gen kodira dvije varijante transkripta.[4]

Reference

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070284 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: GMPPB GDP-mannose pyrophosphorylase B".
  5. ^ "UniProt, Q9Y5P6" (jezik: engleski). Pristupljeno 4. 11. 2021.

Dopunska literatura

Vanjski linkovi

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