GAPDHS
Spermatogena gliceraldehid-3-fosfat dehidrogenaza, znana i kao testisno specifična gliceraldehide-3-fosfat dehidrogenaza, je enzim koji je kod ljudi kodiran genom GAPDHS.[5][6]
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSKRDIVLTN | VTVVQLLRQP | CPVTRAPPPP | EPKAEVEPQP | QPEPTPVREE | ||||
| IKPPPPPLPP | HPATPPPKMV | SVARELTVGI | NGFGRIGRLV | LRACMEKGVK | ||||
| VVAVNDPFID | PEYMVYMFKY | DSTHGRYKGS | VEFRNGQLVV | DNHEISVYQC | ||||
| KEPKQIPWRA | VGSPYVVEST | GVYLSIQAAS | DHISAGAQRV | VISAPSPDAP | ||||
| MFVMGVNEND | YNPGSMNIVS | NASCTTNCLA | PLAKVIHERF | GIVEGLMTTV | ||||
| HSYTATQKTV | DGPSRKAWRD | GRGAHQNIIP | ASTGAAKAVT | KVIPELKGKL | ||||
| TGMAFRVPTP | DVSVVDLTCR | LAQPAPYSAI | KEAVKAAAKG | PMAGILAYTE | ||||
| DEVVSTDFLG | DTHSSIFDAK | AGIALNDNFV | KLISWYDNEY | GYSHRVVDLL | ||||
| RYMFSRDK |
Funkcija
Ovaj gen kodira protein koji pripada gliceraldehid-3-fosfat dehidrogenaza, enzima koji imaju važnu ulogu u metabolizmu ugljikohidrata. Pored ispoljavanja u somatskim ćelijama, ovaj enzim specifičan za spermu, djekuje na nikotinamid adenin-dinukleotid – u zavisnosti od uklanjanja vodika i dodavanja fosfata u gliceraldehid 3-fosfat, da bi se formirao 1,3-difosfoglicerat . Tokom spermiogeneze, ovaj enzim može imati važnu ulogu u regulaciji prebacivanja između različitih puteva za proizvodnju energije, a potreban je za pokretljivost spermatozoida i plodnost muškaraca.[6]
U melanocitnim ćelijama, ekspresija gena GAPDHS može se regulirati pomoću transkripcijskim faktorom povezanim sa mikroftalmijom (MITF).[7]
Mapa interaktivnog puta
Šablon:GlycolysisGluconeogenesis WP534
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105679 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061099 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM (Apr 2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". Journal of Andrology. 21 (2): 328–38. doi:10.1002/j.1939-4640.2000.tb02111.x (neaktivno 13. 1. 2021). PMID 10714828.CS1 održavanje: DOI nije aktivan od 2021 (link)
- ^ a b "Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic".
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
Dopunska literatura
- Cooper TG, Yeung CH (Jun 1999). "Approaches to post-testicular contraception". Asian Journal of Andrology. 1 (1–2): 29–36. PMID 11225901.
- Benham FJ, Povey S (Aug 1989). "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations". Genomics. 5 (2): 209–14. doi:10.1016/0888-7543(89)90048-7. PMID 2793178.
- Peterson RN, Freund M (Apr 1973). "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa". Biology of Reproduction. 8 (3): 350–7. PMID 4349855. Arhivirano s originala (PDF), 23. 9. 2015. Pristupljeno 14. 10. 2011.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Westhoff D, Kamp G (Aug 1997). "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa". Journal of Cell Science. 110 (15): 1821–9. PMID 9264469.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S (Feb 2000). "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa". Molecular Human Reproduction. 6 (2): 127–36. doi:10.1093/molehr/6.2.127. PMID 10655454.
- Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG (2001). "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro". Journal of Andrology. 22 (3): 464–70. PMID 11330647.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, Cravchik A, Ross D, Lau K, Kwok S, Chang SY, Catanese J, Sninsky J, White TJ, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Owen M, Williams J, Goate A, Grupe A (Nov 2004). "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15688–93. Bibcode:2004PNAS..10115688L. doi:10.1073/pnas.0403535101. PMC 524264. PMID 15507493.
- Kodama R, Kondo T, Yokote H, Jing X, Sawada T, Hironishi M, Sakaguchi K (Dec 2005). "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)". Genes to Cells. 10 (12): 1211–9. doi:10.1111/j.1365-2443.2005.00911.x. PMID 16324157. S2CID 22847496.
- Welch JE, Barbee RR, Magyar PL, Bunch DO, O'Brien DA (Aug 2006). "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis". Molecular Reproduction and Development. 73 (8): 1052–60. doi:10.1002/mrd.20235. PMID 16700075. S2CID 6243286.
- Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (Dec 2006). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.
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