FUT2

FUT2
Identifikatori
AliasiFUT2
Vanjski ID-jeviOMIM: 182100 MGI: 109374 HomoloGene: 10325 GeneCards: FUT2
EC broj2.4.1.69 2.4.1.344, 2.4.1.69
Lokacija gena (čovjek)
Hromosom 19 (čovjek)
Hrom.Hromosom 19 (čovjek)[1]
Hromosom 19 (čovjek)
Genomska lokacija za FUT2
Genomska lokacija za FUT2
Bend19q13.33Početak48,695,971 bp[1]
Kraj48,705,951 bp[1]
Lokacija gena (miš)
Hromosom 7 (miš)
Hrom.Hromosom 7 (miš)[2]
Hromosom 7 (miš)
Genomska lokacija za FUT2
Genomska lokacija za FUT2
Bend7 B3|7 29.41 cMPočetak45,298,015 bp[2]
Kraj45,315,818 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
galactoside 2-alpha-L-fucosyltransferase activity
glycosyltransferase activity
fucosyltransferase activity
Ćelijska komponenta integral component of membrane
Golgi cisterna membrane
Golđijev aparat
Egzosom
membrana
Biološki proces GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
L-fucose catabolic process
fucosylation
carbohydrate metabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001097638
NM_000511

NM_001271993
NM_018876

RefSeq (bjelančevina)

NP_000502
NP_001091107

NP_001258922
NP_061364

Lokacija (UCSC)Chr 19: 48.7 – 48.71 MbChr 7: 45.3 – 45.32 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Galaktozid 2-alfa-L-fukoziltransferaza 2 je enzim koji je kod ljudi kodiran genom FUT2.[5][6] Ovaj gen utiče na individualni status sekrecije antgena ABO(H) sistema.[7]

Otprilike 20% kavkazoida su je nesekretori zbog G428A (rs601338) i C571T (rs492602?) i besmislenih mutacija u FUT2 i stoga imaju snažnu, iako ne apsolutnu zaštitu od norovirusa GII.4.

Aminokiselinska sekvenca

Simboli
1020304050
MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLAS
TSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMH
STLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGY
PCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHV
RRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCR
ENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTG
GDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176920 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055978 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.
  6. ^ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".
  7. ^ "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Arhivirano s originala (PDF), 28. 8. 2019. Pristupljeno 13. 10. 2019.

Dupunska literatura

Vanjski linkovi

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