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FNBP4
Identifikatori
Aliasi	FNBP4
Vanjski ID-jevi	OMIM: 615265 MGI: 1860513 HomoloGene: 9087 GeneCards: FNBP4
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	47,767,443 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	90,781,021 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	23360
	55935
	ENSG00000109920; ENSG00000285182
	ENSMUSG00000008200
	Q8N3X1
	Q6ZQ03
	NM_015308; NM_001318339
	NM_018828
	NP_001305268; NP_056123
	NP_061298
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Formin-vezujući protein 4 je protein koji je kod ljudi kodiran genom FNBP4.^[5]^[6]

Pronađene su mutacije u ovom genu povezane sa slučajevima sličnim mikroftalmiji s anomalijama udova.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.o17 aminokiselina, a molekulska težina 110.266 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGKKSRAVPG	RRPILQLSPP	GPRGSTPGRD	PEPEPDTEPD	STAAVPSQPA
PSAATTTTTA	VTAAAASDDS	PSEDEQEAVQ	EVPRVVQNPP	KPVMTTRPTA
VKATGGLCLL	GAYADSDDDD	NDVSEKLAQS	KETNGNQSTD	IDSTLANFLA
EIDAITAPQP	AAPVGASAPP	PTPPRPEPKE	AATSTLSSST	SNGTDSTQTS
GWQYDTQCSL	AGVGIEMGDW	QEVWDENTGC	YYYWNTQTNE	VTWELPQYLA
TQVQGLQHYQ	PSSVPGAETS	FVVNTDIYSK	EKTISVSSSK	SGPVIAKREV
KKEVNEGIQA	LSNSEEEKKG	VAASLLAPLL	PEGIKEEEER	WRRKVICKEE
PVSEVKETST	TVEEATTIVK	PQEIMLDNIE	DPSQEDLCSV	VQSGESEEEE
EQDTLELELV	LERKKAELRA	LEEGDGSVSG	SSPRSDISQP	ASQDGMRRLM
SKRGKWKMFV	RATSPESTSR	SSSKTGRDTP	ENGETAIGAE	NSEKIDENSD
KEMEVEESPE	KIKVQTTPKV	EEEQDLKFQI	GELANTLTSK	FEFLGINRQS
ISNFHVLLLQ	TETRIADWRE	GALNGNYLKR	KLQDAAEQLK	QYEINATPKG
WSCHWDRDHR	RYFYVNEQSG	ESQWEFPDGE	EEEEESQAQE	NRDETLAKQT
LKDKTGTDSN	STESSETSTG	SLCKESFSGQ	VSSSSLMPLT	PFWTLLQSNV
PVLQPPLPLE	MPPPPPPPPE	SPPPPPPPPP	PAEDGEIQEV	EMEDEGSEEP
PAPGTEEDTP	LKPSAQTTVV	TSQSSVDSTI	SSSSSTKGIK	RKATEISTAV
VQRSATIGSS	PVLYSQSAIA	TGHQAAGIGN	QATGIGHQTI	PVSLPAAGMG
HQARGMSLQS	NYLGLAAAPA	IMSYAECSVP	IGVTAPSLQP	VQARGAVPTA
TIIEPPPPPP	PPPPPPPPAP	KMPPPEKTKK	GRKDKAKKSK	TKMPSLVKKW
QSIQRELDEE	DNSSSSEEDR	ESTAQKRIEE	WKQQQLVSGM	AERNANFEAL
PEDWRARLKR	RKMAPNT

Reference

^ ^a ^b ^c ENSG00000285182 GRCh38: Ensembl release 89: ENSG00000109920, ENSG00000285182 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008200 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ "Entrez Gene: FNBP4 formin binding protein 4".
^ "UniProt, Q8N3X1". Pristupljeno 22. 8. 2021.

Dopunska literatura

Bedford MT, Sarbassova D, Xu J, et al. (2000). "A novel pro-Arg motif recognized by WW domains". J. Biol. Chem. 275 (14): 10359–69. doi:10.1074/jbc.275.14.10359. PMID 10744724.
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] ENSG00000285182 GRCh38: Ensembl release 89: ENSG00000109920, ENSG00000285182 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008200 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10231032-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

[entrez-6] "Entrez Gene: FNBP4 formin binding protein 4".

[UniProt-7] "UniProt, Q8N3X1". Pristupljeno 22. 8. 2021.

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FNBP4

Aminokiselinska sekvenca

Reference

Dopunska literatura

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