FCMR

FCMR
Identifikatori
AliasiFCMR
Vanjski ID-jeviOMIM: 606015 MGI: 1916419 HomoloGene: 48347 GeneCards: FCMR
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za FCMR
Genomska lokacija za FCMR
Bend1q32.1Početak206,903,317 bp[1]
Kraj206,923,247 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za FCMR
Genomska lokacija za FCMR
Bend1|1 E4Početak130,793,406 bp[2]
Kraj130,808,528 bp[2]
Ortolozi
VrsteČovjekMiš
Entrez

9214

69169

Ensembl

ENSG00000162894

ENSMUSG00000042474

UniProt

O60667

A1KXC4

RefSeq (mRNK)

NM_001142472
NM_001142473
NM_001193338
NM_005449

NM_026976

RefSeq (bjelančevina)

NP_001135945
NP_001180267
NP_005440

NP_081252
NP_001392822

Lokacija (UCSC)Chr 1: 206.9 – 206.92 MbChr 1: 130.79 – 130.81 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Fc-fragment IgM receptora jest protein koji je kod ljudi kodiran genom FCMR sa hromosoma 1.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 390 aminokiselina, a molekulska težina 43 146 Da.[6]

1020304050
MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCR
EMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSG
VYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQM
PAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDK
PRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQ
GFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQ
RPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVS
ESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA

Funkcija

Fc-receptori se specifično vezuju za Fc-region imunoglobulina (Igs), kako bi posredovali u jedinstvenim funkcijama svake klase Ig. FAIM3 kodira Fc-receptor za IgM (vidi MIM 147020) (Kubagawa et al., 2009. PubMed 19858324]; Shima et al., 2010 PubMed 20042454]).

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162894 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042474 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Fc fragment of IgM receptor". Pristupljeno 24. 3. 2016.
  6. ^ "UniProt, O60667" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

  • Sigruener A, Buechler C, Bared SM, Grandl M, Aslanidis C, Ugocsai P, Gehrmann M, Schmitz G (2007). "E-LDL upregulates TOSO expression and enhances the survival of human macrophages". Biochem. Biophys. Res. Commun. 359 (3): 723–8. doi:10.1016/j.bbrc.2007.05.169. PMID 17553462.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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