DOKUMEN123.COM

EPC1
Identifikatori
Aliasi	EPC1
Vanjski ID-jevi	OMIM: 610999 MGI: 1278322 HomoloGene: 32627 GeneCards: EPC1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	32,378,798 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	6,516,108 bp
Ontologija gena
Molekularna funkcija	• histone acetyltransferase activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• Piccolo NuA4 histone acetyltransferase complex; • Jedarna membrana; • jedro; • NuA4 histone acetyltransferase complex; • nukleoplazma;
Biološki proces	• vascular associated smooth muscle cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • histone H4 acetylation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • histone H2A acetylation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of growth; • negative regulation of gene expression, epigenetic; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of G0 to G1 transition; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	80314
	13831
	ENSG00000120616
	ENSMUSG00000024240
	Q9H2F5
	Q8C9X6
	NM_001272004; NM_001272019; NM_001282391; NM_025209
	NM_001276350; NM_007935; NM_027497
	NP_001258933; NP_001258948; NP_001269320; NP_079485
	NP_001263279; NP_031961; NP_081773
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pojačivač polikombnog homologa 1 je protein koji je kod ljudig kodoran genom EPC1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 836 aminokiselina, а molekulska težina 93.463.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSKLSFRARA	LDASKPLPVF	RCEDLPDLHE	YASINRAVPQ	MPTGMEKEEE
SEHHLQRAIS	AQQVYGEKRD	NMVIPVPEAE	SNIAYYESIY	PGEFKMPKQL
IHIQPFSLDA	EQPDYDLDSE	DEVFVNKLKK	KMDICPLQFE	EMIDRLEKGS
GQQPVSLQEA	KLLLKEDDEL	IREVYEYWIK	KRKNCRGPSL	IPSVKQEKRD
GSSTNDPYVA	FRRRTEKMQT	RKNRKNDEAS	YEKMLKLRRD	LSRAVTILEM
IKRREKSKRE	LLHLTLEIME	KRYNLGDYNG	EIMSEVMAQR	QPMKPTYAIP
IIPITNSSQF	KHQEAMDVKE	FKVNKQDKAD	LIRPKRKYEK	KPKVLPSSAA
ATPQQTSPAA	LPVFNAKDLN	QYDFPSSDEE	PLSQVLSGSS	EAEEDNDPDG
PFAFRRKAGC	QYYAPHLDQT	GNWPWTSPKD	GGLGDVRYRY	CLTTLTVPQR
CIGFARRRVG	RGGRVLLDRA	HSDYDSVFHH	LDLEMLSSPQ	HSPVNQFANT
SETNTSDKSF	SKDLSQILVN	IKSCRWRHFR	PRTPSLHDSD	NDELSCRKLY
RSINRTGTAQ	PGTQTCSTST	QSKSSSGSAH	FAFTAEQYQQ	HQQQLALMQK
QQLAQIQQQQ	ANSNSSTNTS	QNLASNQQKS	GFRLNIQGLE	RTLQGFVSKT
LDSASAQFAA	SALVTSEQLM	GFKMKDDVVL	GIGVNGVLPA	SGVYKGLHLS
STTPTALVHT	SPSTAGSALL	QPSNITQTSS	SHSALSHQVT	AANSATTQVL
IGNNIRLTVP	SSVATVNSIA	PINARHIPRT	LSAVPSSALK	LAAAANCQVS
KVPSSSSVDS	VPRENHESEK	PALNNIADNT	VAMEVT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120616 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024240 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shimono Y, Murakami H, Hasegawa Y, Takahashi M (Jan 2001). "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions". J Biol Chem. 275 (50): 39411–9. doi:10.1074/jbc.M006585200. PMID 10976108.
^ "Entrez Gene: EPC1 enhancer of polycomb homolog 1 (Drosophila)".
^ "UniProt, Q9H2F5". Pristupljeno 1. 9. 2021.

Dopunska literatura

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Liedtke W, Meyer G, Faustmann PM, et al. (1997). "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients". Int. Immunol. 9 (7): 1031–41. doi:10.1093/intimm/9.7.1031. PMID 9237112.
Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
Kenny TP, Semrad TJ, Malyj W, Robbins DL (2001). "Mutational analysis of immunoglobulin germline derived Vlambda4B light chains in rheumatoid arthritis". Clin. Immunol. 99 (2): 283–90. doi:10.1006/clim.2001.5020. PMID 11318600.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Attwooll C, Oddi S, Cartwright P, et al. (2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10.1074/jbc.M412509200. PMID 15536069.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120616 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024240 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10976108-5] Shimono Y, Murakami H, Hasegawa Y, Takahashi M (Jan 2001). "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions". J Biol Chem. 275 (50): 39411–9. doi:10.1074/jbc.M006585200. PMID 10976108.

[entrez-6] "Entrez Gene: EPC1 enhancer of polycomb homolog 1 (Drosophila)".

[UniProt-7] "UniProt, Q9H2F5". Pristupljeno 1. 9. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

EPC1

Aminokiselinska sekvenca

Reference

Dopunska literatura

Content Disclaimer