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ENTPD3
Identifikatori
Aliasi	ENTPD3
Vanjski ID-jevi	OMIM: 603161 MGI: 1321386 HomoloGene: 68171 GeneCards: ENTPD3
EC broj	3.6.1.5
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	40,428,744 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	120,397,393 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • ATP binding; • nucleoside-diphosphatase activity; • nucleoside-triphosphatase activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • ćelijska membrana;
Biološki proces	• nucleoside triphosphate catabolic process; • nucleoside diphosphate catabolic process; • nucleobase-containing small molecule catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	956
	215446
	ENSG00000168032
	ENSMUSG00000041608
	O75355
	Q8BFW6
	NM_001248; NM_001291960; NM_001291961
	NM_178676
	NP_001239; NP_001278889; NP_001278890
	NP_848791
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ektonukleozid-trifosfat difosfohidrolaza 3 jest enzim koji je kod ljudi kodiran genom ENTPD3 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 529 aminokiselina, а molekulska težina 59.105 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFTVLTRQPC	EQAGLKALYR	TPTIIALVVL	LVSIVVLVSI	TVIQIHKQEV
LPPGLKYGIV	LDAGSSRTTV	YVYQWPAEKE	NNTGVVSQTF	KCSVKGSGIS
SYGNNPQDVP	RAFEECMQKV	KGQVPSHLHG	STPIHLGATA	GMRLLRLQNE
TAANEVLESI	QSYFKSQPFD	FRGAQIISGQ	EEGVYGWITA	NYLMGNFLEK
NLWHMWVHPH	GVETTGALDL	GGASTQISFV	AGEKMDLNTS	DIMQVSLYGY
VYTLYTHSFQ	CYGRNEAEKK	FLAMLLQNSP	TKNHLTNPCY	PRDYSISFTM
GHVFDSLCTV	DQRPESYNPN	DVITFEGTGD	PSLCKEKVAS	IFDFKACHDQ
ETCSFDGVYQ	PKIKGPFVAF	AGFYYTASAL	NLSGSFSLDT	FNSSTWNFCS
QNWSQLPLLL	PKFDEVYARS	YCFSANYIYH	LFVNGYKFTE	ETWPQIHFEK
EVGNSSIAWS	LGYMLSLTNQ	IPAESPLIRL	PIEPPVFVGT	LAFFTAAALL
CLAFLAYLCS	ATRRKRHSEH	AFDHAVDSD

Funkcija

ENTPD3 je sličan nukleotidazama E-tipa (NTPaza). NTPaze, kao što je CD39, posreduju katabolizam vanćelijskih nukleotida. ENTPD3 sadrži četiri apirazno konzervirane regije, što je karakteristično za NTPaze.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
^ ^a ^b "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".
^ "UniProt, O75355" (jezik: engleski). Pristupljeno 3. 11. 2021.

Dopunska literatura

Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists". Biochem. Pharmacol. 74 (10): 1524–34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling". Biochemistry. 44 (25): 8998–9012. doi:10.1021/bi047487z. PMID 15966724.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions". Biochemistry. 40 (13): 3943–50. doi:10.1021/bi002711f. PMID 11300774.
Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase". Biochemistry. 38 (18): 5849–57. doi:10.1021/bi990171k. PMID 10231536.
Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1". Biochim. Biophys. Acta. 1386 (1): 65–78. doi:10.1016/s0167-4838(98)00063-6. PMID 9675246.
Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm. Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9676430-5] Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.

[entrez-6] "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".

[UniProt-7] "UniProt, O75355" (jezik: engleski). Pristupljeno 3. 11. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak

ENTPD3

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

Vanjski linkovi

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