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ENTPD2
Identifikatori
Aliasi	ENTPD2
Vanjski ID-jevi	OMIM: 602012 MGI: 1096863 HomoloGene: 20333 GeneCards: ENTPD2
EC broj	3.6.1.5
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	137,054,061 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	25,291,333 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • nucleoside-diphosphatase activity; • hydrolase activity; • ATP binding; • nucleoside-triphosphatase activity;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum; • Egzosom; • ćelijska membrana; • basement membrane;
Biološki proces	• G protein-coupled receptor signaling pathway; • purine ribonucleoside diphosphate catabolic process; • platelet activation; • nucleobase-containing small molecule catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	954
	12496
	ENSG00000054179
	ENSMUSG00000015085
	Q9Y5L3
	O55026
	NM_001246; NM_203468
	NM_009849
	NP_001237; NP_982293
	NP_033979
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ektonukleozid trifosfat-difosfohidrolaza 2 je enzim koji je kod ljudi kodiran genom ENTPD2.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 495 aminokiselina, а molekulska težina 53.665 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGKVRSLLP	PLLLAAAGLA	GLLLLCVPTR	DVREPPALKY	GIVLDAGSSH
TSMFIYKWPA	DKENDTGIVG	QHSSCDVPGG	GISSYADNPS	GASQSLVGCL
EQALQDVPKE	RHAGTPLYLG	ATAGMRLLNL	TNPEASTSVL	MAVTHTLTQY
PFDFRGARIL	SGQEEGVFGW	VTANYLLENF	IKYGWVGRWF	RPRKGTLGAM
DLGGASTQIT	FETTSPAEDR	ASEVQLHLYG	QHYRVYTHSF	LCYGRDQVLQ
RLLASALQTH	GFHPCWPRGF	STQVLLGDVY	QSPCTMAQRP	QNFNSSARVS
LSGSSDPHLC	RDLVSGLFSF	SSCPFSRCSF	NGVFQPPVAG	NFVAFSAFFY
TVDFLRTSMG	LPVATLQQLE	AAAVNVCNQT	WAQLQARVPG	QRARLADYCA
GAMFVQQLLS	RGYGFDERAF	GGVIFQKKAA	DTAVGWALGY	MLNLTNLIPA
DPPGLRKGTD	FSSWVVLLLL	FASALLAALV	LLLRQVHSAK	LPSTI

Funkcija

Protein kodiran ovim genom je enzim tipa 2, iz porodice ekto-nukleozid trifosfat difosfohidrolaza (E-NTPDaza). E-NTPDaze su porodica ekto-nukleozidaza koje hidroliziraju 5'-trifosfate. Ova ekto-ATPaza je integralni membranski protein. Alternativna prerada ovog gena dovodi do više varijanti transkripta.^[6]

Naučnici sa Univerziteta u Warwicku pokazali su da E-NTPDaza 2 stimulira rast ljudskog oka: tretiranjem enzima na punoglavcima, otkriveno je da dobijaju dodatne oči na svom tijelu.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054179 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015085 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
^ ^a ^b "Entrez Gene: ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2".
^ "UniProt, Q9Y5L3". Pristupljeno 8. 9. 2021.

Dopunska literatura

Javed R, Yarimizu K, Pelletier N, et al. (2007). "Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2)". Biochemistry. 46 (22): 6617–27. doi:10.1021/bi700036e. PMID 17489562.
Mukasa T, Lee Y, Knowles AF (2005). "Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8)". Biochemistry. 44 (33): 11160–70. doi:10.1021/bi050019k. PMID 16101300.
Jhandier MN, Kruglov EA, Lavoie EG, et al. (2005). "Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2". J. Biol. Chem. 280 (24): 22986–92. doi:10.1074/jbc.M412371200. PMID 15799977.
Dranoff JA, Kruglov EA, Toure J, et al. (2005). "Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis". J. Investig. Med. 52 (7): 475–82. doi:10.2310/6650.2004.00710. PMID 15651265.
Alvarado-Castillo C, Harden TK, Boyer JL (2005). "Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2". Mol. Pharmacol. 67 (1): 114–22. doi:10.1124/mol.104.006908. PMID 15496502. S2CID 27764870.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Knowles AF, Chiang WC (2003). "Enzymatic and transcriptional regulation of human ecto-ATPase/E-NTPDase 2". Arch. Biochem. Biophys. 418 (2): 217–27. doi:10.1016/j.abb.2003.08.007. PMID 14522593.
Mateo J, Kreda S, Henry CE, et al. (2003). "Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme". J. Biol. Chem. 278 (41): 39960–8. doi:10.1074/jbc.M307854200. PMID 12888562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grinthal A, Guidotti G (2002). "Transmembrane domains confer different substrate specificities and adenosine diphosphate hydrolysis mechanisms on CD39, CD39L1, and chimeras". Biochemistry. 41 (6): 1947–56. doi:10.1021/bi015563h. PMID 11827541.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Mateo J, Harden TK, Boyer JL (2000). "Functional expression of a cDNA encoding a human ecto-ATPase". Br. J. Pharmacol. 128 (2): 396–402. doi:10.1038/sj.bjp.0702805. PMC 1571647. PMID 10510450.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054179 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015085 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9271669-5] Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.

[entrez-6] "Entrez Gene: ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2".

[UniProt-7] "UniProt, Q9Y5L3". Pristupljeno 8. 9. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak

ENTPD2

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

Vanjski linkovi

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