DOM3Z
Protein Dom3Z jest protein koji je kod ljudi kodiran genom DOM3Z.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 396 aminokiselina, а molekulska težina 44.929 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDPRGTKRGA | EKTEVAEPRN | KLPRPAPSLP | TDPALYSGPF | PFYRRPSELG | ||||
| CFSLDAQRQY | HGDARALRYY | SPPPTNGPGP | NFDLRDGYPD | RYQPRDEEVQ | ||||
| ERLDHLLCWL | LEHRGRLEGG | PGWLAEAIVT | WRGHLTKLLT | TPYERQEGWQ | ||||
| LAASRFQGTL | YLSEVETPNA | RAQRLARPPL | LRELMYMGYK | FEQYMCADKP | ||||
| GSSPDPSGEV | NTNVAFCSVL | RSRLGSHPLL | FSGEVDCTDP | QAPSTQPPTC | ||||
| YVELKTSKEM | HSPGQWRSFY | RHKLLKWWAQ | SFLPGVPNVV | AGFRNPDGFV | ||||
| SSLKTFPTMK | MFEYVRNDRD | GWNPSVCMNF | CAAFLSFAQS | TVVQDDPRLV | ||||
| HLFSWEPGGP | VTVSVHQDAP | YAFLPIWYVE | AMTQDLPSPP | KTPSPK |
Funkcija
Ovaj gen se lokalizira u glavnom kompleksu histokompatibilnosti (MHC) klase III na hromosomu 6. Funkcija njegovog proteinskog proizvoda je nepoznata, ali njegova sveprisutna ekspresija i konzeviranost i kod jednostavnih i kod složenih eukariota sugerira da bi to moglo biti domaćinski gen.[6]
Reference
- ^ a b c ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040482 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
- ^ a b "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".
- ^ "UniProt, O77932" (jezik: engleski). Pristupljeno 1. 10. 2021.
Dopunska literatura
- Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. S2CID 25061446.
- Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. Immunogenet. 17 (1): 1–17. doi:10.1159/000019119. PMID 10686478. S2CID 45164668.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.