DCLK3

DCLK3
Identifikatori
AliasiDCLK3
Vanjski ID-jeviOMIM: 613167 MGI: 3039580 HomoloGene: 70580 GeneCards: DCLK3
EC broj2.7.11.1
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za DCLK3
Genomska lokacija za DCLK3
Bend3p22.2Početak36,712,421 bp[1]
Kraj36,764,553 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za DCLK3
Genomska lokacija za DCLK3
Bend9|9 F3Početak111,268,149 bp[2]
Kraj111,318,186 bp[2]
Ontologija gena
Molekularna funkcija• aktivnost sa transferazom
• nucleotide binding
• protein kinase activity
• ATP binding
• kinase activity
• protein serine/threonine kinase activity
Ćelijska komponenta• jedro
• citoplazma
Biološki proces• protein phosphorylation
• Fosforilacija
• negative regulation of protein localization to nucleus
• GO:0035404 peptidyl-serine phosphorylation
• peptidyl-threonine phosphorylation
• GO:0007243 intracellular signal transduction
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

85443

245038

Ensembl

ENSG00000163673

ENSMUSG00000032500

UniProt

Q9C098

Q8BWQ5

RefSeq (mRNK)

NM_033403
NM_001394672

NM_172928

RefSeq (bjelančevina)

NP_208382

NP_766516

Lokacija (UCSC)Chr 3: 36.71 – 36.76 MbChr 9: 111.27 – 111.32 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Dvojnokortinolika kinaza 3 jest enzim koji je kod ljudi kodiran genom DCLK3 sa hromosoma 3.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 648 aminokiselina, а molekulska težina 73.814 Da.[6]

1020304050
MGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKG
DHRCGETETPKSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKW
EPEPSSKPPREATLEERHARGEKHLGVEIEKTSGEIIRCEKCKRERELQQ
SLERERLSLGTSELDMGKGPMYDVEKLVRTRSCRRSPEANPASGEEGWKG
DSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAAKAKKDLVEVL
PVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKE
KKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAA
NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVD
SEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFP
EPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADF
GLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGF
PPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKK
RYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163673 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032500 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Doublecortin like kinase 3". Pristupljeno 3. 4. 2016.
  6. ^ "UniProt, Q9C098" (jezik: англ.). Pristupljeno 3. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Vanjski linkovi

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