DOKUMEN123.COM

CHTOP
Identifikatori
Aliasi	CHTOP
Vanjski ID-jevi	OMIM: 614206 MGI: 1913761 HomoloGene: 134556 GeneCards: CHTOP
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	153,646,306 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	90,416,805 bp
Ontologija gena
Molekularna funkcija	• methyl-CpG binding; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• nuclear speck; • Jedarce; • transcription export complex; • jedro; • nukleoplazma; • cytoplasmic ribonucleoprotein granule;
Biološki proces	• mRNA transport; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of ATP-dependent activity; • positive regulation of helicase activity; • positive regulation of histone methylation; • transcription, DNA-templated; • positive regulation of cell population proliferation; • RNA export from nucleus; • termination of RNA polymerase II transcription; • mRNA export from nucleus; • mRNA 3'-end processing; • GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	26097
	66511
	ENSG00000160679
	ENSMUSG00000001017
	Q9Y3Y2
	Q9CY57
	NM_001206612; NM_001244664; NM_015607; NM_001317077
NM_001293776; NM_001293777; NM_001293778; NM_001293779; NM_001293780;
	NM_001293781; NM_001293782; NM_023215
	NP_001193541; NP_001231593; NP_001304006; NP_056422
NP_001280705; NP_001280706; NP_001280707; NP_001280708; NP_001280709;
	NP_001280710; NP_001280711; NP_075704
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hromatinski ciljni PRMT1 jest protein koji je kod ljudi kodiran genom CHTOP sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Ovaj gen kodira mali jedarni protein koji karakterizira argininom i glicin bogata regija. Kodirani protein može biti uključen u progresiju ćelijskog ciklusa. Ovaj protein stupa u interakciju s proteinskim arginin-metiltransferazama i ima ulogu u aktivaciji transkripcije zavisne od estradiola. Alternativna prerada rezultira višestrukim varijantama transkripta.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160679 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001017 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Chromatin target of PRMT1".
^ "UniProt, Q9Y3Y2" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Zullo AJ, Michaud M, Zhang W, Grusby MJ (maj 2009). "Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation". The Journal of Biological Chemistry. 284 (18): 12504–11. doi:10.1074/jbc.M809436200. PMC 2673316. PMID 19254951.
Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (februar 2013). "Chtop is a component of the dynamic TREX mRNA export complex". The EMBO Journal. 32 (3): 473–86. doi:10.1038/emboj.2012.342. PMC 3567497. PMID 23299939.
Teng IF, Wilson SA (2013). "Mapping interactions between mRNA export factors in living cells". PLOS ONE. 8 (6): e67676. Bibcode:2013PLoSO...867676T. doi:10.1371/journal.pone.0067676. PMC 3691119. PMID 23826332.
van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (januar 2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases". Molecular and Cellular Biology. 30 (1): 260–72. doi:10.1128/MCB.00645-09. PMC 2798285. PMID 19858291.
van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (novembar 2010). "Fetal globin expression is regulated by Friend of Prmt1". Blood. 116 (20): 4349–52. doi:10.1182/blood-2010-03-274399. PMC 2993632. PMID 20688955.