CHRAC1

CHRAC1
Identifikatori
AliasiCHRAC1
Vanjski ID-jeviOMIM: 607268 MGI: 2135796 HomoloGene: 41174 GeneCards: CHRAC1
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za CHRAC1
Genomska lokacija za CHRAC1
Bend8q24.3Početak140,511,311 bp[1]
Kraj140,517,154 bp[1]
Lokacija gena (miš)
Hromosom 15 (miš)
Hrom.Hromosom 15 (miš)[2]
Hromosom 15 (miš)
Genomska lokacija za CHRAC1
Genomska lokacija za CHRAC1
Bend15|15 D3Početak72,962,241 bp[2]
Kraj72,969,403 bp[2]
Ontologija gena
Molekularna funkcija• aktivnost sa transferazom
• vezivanje sa DNK
• DNA-directed DNA polymerase activity
• nucleotidyltransferase activity
• GO:0001948, GO:0016582 vezivanje za proteine
• protein heterodimerization activity
Ćelijska komponenta• epsilon DNA polymerase complex
• jedro
• CHRAC
Biološki proces• DNA biosynthetic process
• chromatin remodeling
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

54108

93696

Ensembl

ENSG00000104472

ENSMUSG00000068391

UniProt

Q9NRG0

Q9JKP8

RefSeq (mRNK)

NM_017444

NM_053068

RefSeq (bjelančevina)

NP_059140

NP_444298

Lokacija (UCSC)Chr 8: 140.51 – 140.52 MbChr 15: 72.96 – 72.97 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 1 dostupnosti hromatinskog kompleksa je protein koji je kod ljudi kodiran genom CHRAC1.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 131 aminokiselina, а molekulska težina Da. 14 711[6]

1020304050
MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATE
LFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILA
SKYLKMLKEEKREEDEENDNDNESDHDEADS

Funkcija

CHRAC1 je protein sa histonskim savijanjem koji stupa u interakciju s drugim proteinima sa histonskim naborima kako bi ih vezao neocisno o sekvenci DNK. Ovi dimerski proteini u obliku histonskih nabora kombiniraju se u većim enzimskim kompleksima za transkripciju, replikaciju i pakiranje DNK.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104472 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068391 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Chromatin accessibility complex 1". Pristupljeno 26. 10. 2016.
  6. ^ "UniProt, Q9NRG0" (jezik: engleski). Pristupljeno 15. 9. 2021.

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