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CDNF
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2LPN, 2W50, 4BIT
Identifikatori
Aliasi	CDNF
Vanjski ID-jevi	OMIM: 611233 MGI: 3606576 HomoloGene: 27965 GeneCards: CDNF
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	14,838,575 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	3,527,413 bp
Ontologija gena
Molekularna funkcija	• growth factor activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko; • Endoplazmatski retikulum;
Biološki proces	• neuron projection development; • dopaminergic neuron differentiation; • regulation of signaling receptor activity; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	441549
	227526
	ENSG00000185267
	ENSMUSG00000039496
	Q49AH0
	Q8CC36
	NM_001029954
	NM_177647
	NP_001025125
	NP_808315
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cerebralni dopaminski neurotrofilni faktor, znan i kao ARMET-liki protein 1 jest protein koji je kod ljudi kodiran genom CDNF.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 187 aminokiselina, а molekulska težina 20.969.5^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MWCASPVAVV	AFCAGLLVSH	PVLTQGQEAG	GRPGADCEVC	KEFLNRFYKS
LIDRGVNFSL	DTIEKELISF	CLDTKGKENR	LCYYLGATKD	AATKILSEVT
RPMSVHMPAM	KICEKLKKLD	SQICELKYEK	TLDLASVDLR	KMRVAELKQI
LHSWGEECRA	CAEKTDYVNL	IQELAPKYAA	THPKTEL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185267 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039496 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Cerebral dopamine neurotrophic factor".
^ Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M (Jul 2007). "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo". Nature. 448 (7149): 73–7. doi:10.1038/nature05957. PMID 17611540. S2CID 4409832.
^ "UniProt, Q49AH0". Pristupljeno 31. 8. 2021.

Dopunska literatura

Choi JM, Hong JH, Chae MJ, Ngyuen PH, Kang HS, Ma HI, Kim YJ (Apr 2011). "Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease". Neuroscience Letters. 493 (3): 97–101. doi:10.1016/j.neulet.2011.02.013. PMID 21320571. S2CID 207133072.
Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (Dec 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, O'Brien CP, Kampman KM, Oslin DW (Apr 2009). "Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence". Neuroscience Letters. 453 (3): 199–203. doi:10.1016/j.neulet.2009.02.026. PMC 2680755. PMID 19429035.
Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A (Apr 2009). "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional". Protein Engineering, Design & Selection. 22 (4): 233–41. doi:10.1093/protein/gzn080. PMID 19258449.

Vanjski linkovi

Q49AH0

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185267 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039496 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cerebral dopamine neurotrophic factor".

[pmid17611540-6] Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M (Jul 2007). "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo". Nature. 448 (7149): 73–7. doi:10.1038/nature05957. PMID 17611540. S2CID 4409832.

[UniProt-7] "UniProt, Q49AH0". Pristupljeno 31. 8. 2021.

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CDNF

Aminokiselinska sekvenca

Reference

Dopunska literatura

Vanjski linkovi

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