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CCDC80
Identifikatori
Aliasi	CCDC80
Vanjski ID-jevi	OMIM: 608298 MGI: 1915146 HomoloGene: 12206 GeneCards: CCDC80
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	112,649,530 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	44,948,440 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• fibronectin binding; • glycosaminoglycan binding; • heparin binding;
Ćelijska komponenta	• extracellular region; • basement membrane; • interstitial matrix; • GO:0005578 Vanćelijski matriks;
Biološki proces	• extracellular matrix organization; • positive regulation of cell-substrate adhesion; • response to bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	151887
	67896
	ENSG00000091986
	ENSMUSG00000022665
	Q76M96
	Q8R2G6
	NM_199512; NM_199511; NM_178274
	NM_026439
	NP_955805; NP_955806
	NP_080715
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 80 sa upredenom zavojnicom jest protein koji je kod ljudi kodiran genom CCDC80 sa hromosoma 3.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 950 aminokiselina, а molekulska težina 108.174 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTWRMGPRFT	MLLAMWLVCG	SEPHPHATIR	GSHGGRKVPL	VSPDSSRPAR
FLRHTGRSRG	IERSTLEEPN	LQPLQRRRSV	PVLRLARPTE	PPARSDINGA
AVRPEQRPAA	RGSPREMIRD	EGSSARSRML	RFPSGSSSPN	ILASFAGKNR
VWVISAPHAS	EGYYRLMMSL	LKDDVYCELA	ERHIQQIVLF	HQAGEEGGKV
RRITSEGQIL	EQPLDPSLIP	KLMSFLKLEK	GKFGMVLLKK	TLQVEERYPY
PVRLEAMYEV	IDQGPIRRIE	KIRQKGFVQK	CKASGVEGQV	VAEGNDGGGG
AGRPSLGSEK	KKEDPRRAQV	PPTRESRVKV	LRKLAATAPA	LPQPPSTPRA
TTLPPAPATT	VTRSTSRAVT	VAARPMTTTA	FPTTQRPWTP	SPSHRPPTTT
EVITARRPSV	SENLYPPSRK	DQHRERPQTT	RRPSKATSLE	SFTNAPPTTI
SEPSTRAAGP	GRFRDNRMDR	REHGHRDPNV	VPGPPKPAKE	KPPKKKAQDK
ILSNEYEEKY	DLSRPTASQL	EDELQVGNVP	LKKAKESKKH	EKLEKPEKEK
KKKMKNENAD	KLLKSEKQMK	KSEKKSKQEK	EKSKKKKGGK	TEQDGYQKPT
NKHFTQSPKK	SVADLLGSFE	GKRRLLLITA	PKAENNMYVQ	QRDEYLESFC
KMATRKISVI	TIFGPVNNST	MKIDHFQLDN	EKPMRVVDDE	DLVDQRLISE
LRKEYGMTYN	DFFMVLTDVD	LRVKQYYEVP	ITMKSVFDLI	DTFQSRIKDM
EKQKKEGIVC	KEDKKQSLEN	FLSRFRWRRR	LLVISAPNDE	DWAYSQQLSA
LSGQACNFGL	RHITILKLLG	VGEEVGGVLE	LFPINGSSVV	EREDVPAHLV
KDIRNYFQVS	PEYFSMLLVG	KDGNVKSWYP	SPMWSMVIVY	DLIDSMQLRR
QEMAIQQSLG	MRCPEDEYAG	YGYHSYHQGY	QDGYQDDYRH	HESYHHGYPY

Funkcija

Bioinformatička analiza sugerira da je protein CCDC80 peroksiredoksin.^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091986 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022665 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonaldo MF, Lennon G, Soares MB (maj 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
^ Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.
^ "Entrez Gene: CCDC80 coiled-coil domain containing 80".
^ "UniProt, Q76M96" (jezik: engleski). Pristupljeno 6. 11. 2021.
^ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Dopunska literatura

Okada T, Nishizawa H, Kurata A, et al. (2008). "URB is abundantly expressed in adipose tissue and dysregulated in obesity". Biochem. Biophys. Res. Commun. 367 (2): 370–6. doi:10.1016/j.bbrc.2007.12.164. PMID 18178152.
Cha SY, Sung YK, Im S, et al. (2005). "URB expression in human dermal papilla cells". J. Dermatol. Sci. 39 (2): 128–30. doi:10.1016/j.jdermsci.2005.05.005. PMID 15998583.
Bommer GT, Jäger C, Dürr EM, et al. (2005). "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells". J. Biol. Chem. 280 (9): 7962–75. doi:10.1074/jbc.M412593200. PMID 15563452.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Aoki K, Sun YJ, Aoki S, et al. (2002). "Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3". Biochem. Biophys. Res. Commun. 290 (4): 1282–8. doi:10.1006/bbrc.2002.6337. PMID 11812002.

Vanjski linkovi

Lokacija ljudskog genoma CCDC80 i stranica sa detaljima o genu CCDC80 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091986 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022665 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8889548-5] Bonaldo MF, Lennon G, Soares MB (maj 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[pmid15325258-6] Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.

[entrez-7] "Entrez Gene: CCDC80 coiled-coil domain containing 80".

[UniProt-8] "UniProt, Q76M96" (jezik: engleski). Pristupljeno 6. 11. 2021.

[pmid20964819-9] Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

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CCDC80

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

Vanjski linkovi

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