CBX7
Hromoboksni homolog 7 jest protein koji je kod ljudi kodiran genom CBX7 sa hromosoma 22.[5] Pokazalo se da gubitak ekspresija gena CBX7 korelira sa malignim oblikom karcinomom štitnjače.[6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 251 aminokiselina, a molekulska težina 28.341 Da.
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MELSAIGEQV | FAVESIRKKR | VRKGKVEYLV | KWKGWPPKYS | TWEPEEHILD | ||||
| PRLVMAYEEK | EERDRASGYR | KRGPKPKRLL | LQRLYSMDLR | SSHKAKGKEK | ||||
| LCFSLTCPLG | SGSPEGVVKA | GAPELVDKGP | LVPTLPFPLR | KPRKAHKYLR | ||||
| LSRKKFPPRG | PNLESHSHRR | ELFLQEPPAP | DVLQAAGEWE | PAAQPPEEEA | ||||
| DADLAEGPPP | WTPALPSSEV | TVTDITANSI | TVTFREAQAA | EGFFRDRSGK | ||||
| F |
Modelni organizmi
| Svojstvo | Fenotip |
|---|---|
| Vijabilnost homozigota | Normalan |
| Plodnost | Normalan |
| Tlelesna težina | Normalan |
| Anksioznost otvorenog polja | Normalan |
| Neurološka procjena | Normalan |
| Snaga stiska | Normalan |
| Test vruće ploče | Normalan |
| Dismorfologija | Normalan |
| Indirektna kalorimetrija | Normalan |
| Test tolerancije glukoze | Normalan |
| Senzorni odgovor moždanog stabla | Normalan |
| DEXA | Normalan |
| Radiografija | Normalan |
| Tjelesna temperatura | Nenormalan[7] |
| Morfologija oka | Normalan |
| Klinička hemija | Normalan |
| Plazmatski imunoglobulini | Normalan |
| Hematologija | Nenormalan[8] |
| Limfociti periferne krvi | Normalan |
| Mikronukleus test | Normalan |
| Težina srca | Normalan |
| Cjelocitost repne epiderme | Nenormalan |
| Histopatologija kože | Normalan |
| Histopatologija mozga | Normalan |
| Salmonella infekcija | Normalan[9] |
| Citrobacter infekcija | Normalan[10] |
| Svi testovi i analise su sa linka[11][12] |
Obavljeno je 26 testova i prijavljena su tri značajno nenormalna fenotipa. Homozigotne mutantne odrasle ženke pokazale su smanjen odgovor na hipertermiju izazvanu stresom i imale su povećan broj crvenih krvnih zrnaca. Kada je pregledana epiderma repa, životinje oba spola imale su fenotip integumenta.[11]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100307 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053411 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Chromobox homolog 7". Pristupljeno 2011-12-06.
- ^ Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, et al. (August 2008). "Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer". Cancer Research. 68 (16): 6770–8. doi:10.1158/0008-5472.CAN-08-0695. PMID 18701502.
- ^ "Body temperature data for Cbx7". Wellcome Trust Sanger Institute.
- ^ "Haematology data for Cbx7". Wellcome Trust Sanger Institute.
- ^ "Salmonella infection data for Cbx7". Wellcome Trust Sanger Institute.
- ^ "Citrobacter infection data for Cbx7". Wellcome Trust Sanger Institute.
- ^ a b Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
- ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
Dopunska literatura
- Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a". Molecular Cell. 38 (5): 662–74. doi:10.1016/j.molcel.2010.03.021. PMC 2886305. PMID 20541999.
- Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, et al. (September 2009). "Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein". Cancer Research. 69 (17): 7079–87. doi:10.1158/0008-5472.CAN-09-1542. PMID 19706751.
- Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, et al. (August 2010). "The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients". European Journal of Cancer. 46 (12): 2304–13. doi:10.1016/j.ejca.2010.05.011. PMID 20542683.
- Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, et al. (August 2010). "Oncogenic role of the chromobox protein CBX7 in gastric cancer". Journal of Experimental & Clinical Cancer Research. 29 (1): 114. doi:10.1186/1756-9966-29-114. PMC 2933612. PMID 20723236.
- Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A (February 2020). "Vertebrate diapause preserves organisms long term through Polycomb complex members". Science. 367 (6480): 870–874. doi:10.1126/science.aaw2601. PMC 7532943. PMID 32079766.
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